FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214825142> ?p ?o ?g. }

• W4214825142 abstract "Current diagnostic criteria for schizophrenia place emphasis on delusions and hallucinations, whereas the classical descriptions of schizophrenia by Kraepelin and Bleuler emphasized disorganization and impoverishment of mental activity. Despite the availability of antipsychotic medication for treating delusions and hallucinations, many patients continue to experience persisting disability. Improving treatment requires a better understanding of the processes leading to persisting disability. We recently introduced the term classical schizophrenia to describe cases with disorganized and impoverished mental activity, cognitive impairment and predisposition to persisting disability. Recent evidence reveals that a polygenic score indicating risk for schizophrenia predicts severity of the features of classical schizophrenia: disorganization, and to a lesser extent, impoverishment of mental activity and cognitive impairment. Current understanding of brain function attributes a cardinal role to predictive coding: the process of generating models of the world that are successively updated in light of confirmation or contradiction by subsequent sensory information. It has been proposed that abnormalities of these predictive processes account for delusions and hallucinations. Here we examine the evidence provided by electrophysiology and fMRI indicating that imprecise predictive coding is the core pathological process in classical schizophrenia, accounting for disorganization, psychomotor poverty and cognitive impairment. Functional imaging reveals aberrant brain activity at network hubs engaged during encoding of predictions. We discuss the possibility that frequent prediction errors might promote excess release of the neurotransmitter, dopamine, thereby accounting for the occurrence of episodes of florid psychotic symptoms including delusions and hallucinations in classical schizophrenia. While the predictive coding hypotheses partially accounts for the time-course of classical schizophrenia, the overall body of evidence indicates that environmental factors also contribute. We discuss the evidence that chronic inflammation is a mechanism that might link diverse genetic and environmental etiological factors, and contribute to the proposed imprecision of predictive coding." @default.
• W4214825142 created "2022-03-05" @default.
• W4214825142 creator A5021933478 @default.
• W4214825142 creator A5036975863 @default.
• W4214825142 date "2022-03-03" @default.
• W4214825142 modified "2023-09-29" @default.
• W4214825142 title "Imprecise Predictive Coding Is at the Core of Classical Schizophrenia" @default.
• W4214825142 cites W116437946 @default.
• W4214825142 cites W1267646904 @default.
• W4214825142 cites W1559088113 @default.
• W4214825142 cites W1779974355 @default.
• W4214825142 cites W1902335101 @default.
• W4214825142 cites W1924382915 @default.
• W4214825142 cites W1968315723 @default.
• W4214825142 cites W1968899037 @default.
• W4214825142 cites W1970220307 @default.
• W4214825142 cites W1978997011 @default.
• W4214825142 cites W1987291701 @default.
• W4214825142 cites W1999992635 @default.
• W4214825142 cites W2005821483 @default.
• W4214825142 cites W2014596655 @default.
• W4214825142 cites W2017606531 @default.
• W4214825142 cites W2019410645 @default.
• W4214825142 cites W2023475151 @default.
• W4214825142 cites W2034685785 @default.
• W4214825142 cites W2042798191 @default.
• W4214825142 cites W2046429124 @default.
• W4214825142 cites W2046716239 @default.
• W4214825142 cites W2051850587 @default.
• W4214825142 cites W2055345898 @default.
• W4214825142 cites W2055368975 @default.
• W4214825142 cites W2059566633 @default.
• W4214825142 cites W2059846601 @default.
• W4214825142 cites W2061509809 @default.
• W4214825142 cites W2065540111 @default.
• W4214825142 cites W2074594680 @default.
• W4214825142 cites W2083614671 @default.
• W4214825142 cites W2090801042 @default.
• W4214825142 cites W2099159042 @default.
• W4214825142 cites W2109059823 @default.
• W4214825142 cites W2112023200 @default.
• W4214825142 cites W2116658855 @default.
• W4214825142 cites W2118030136 @default.
• W4214825142 cites W2119619841 @default.
• W4214825142 cites W2119885245 @default.
• W4214825142 cites W2125386334 @default.
• W4214825142 cites W2126843605 @default.
• W4214825142 cites W2128062940 @default.
• W4214825142 cites W2131918913 @default.
• W4214825142 cites W2140487181 @default.
• W4214825142 cites W2140606211 @default.
• W4214825142 cites W2142009972 @default.
• W4214825142 cites W2145566493 @default.
• W4214825142 cites W2147666048 @default.
• W4214825142 cites W2156025382 @default.
• W4214825142 cites W2157376352 @default.
• W4214825142 cites W2159387402 @default.
• W4214825142 cites W2160328559 @default.
• W4214825142 cites W2163200475 @default.
• W4214825142 cites W2166793287 @default.
• W4214825142 cites W2167121714 @default.
• W4214825142 cites W2169365717 @default.
• W4214825142 cites W2171191846 @default.
• W4214825142 cites W2178644161 @default.
• W4214825142 cites W2196103100 @default.
• W4214825142 cites W2270360904 @default.
• W4214825142 cites W2290843969 @default.
• W4214825142 cites W2504479060 @default.
• W4214825142 cites W2604132829 @default.
• W4214825142 cites W2770633884 @default.
• W4214825142 cites W2791381106 @default.
• W4214825142 cites W2804318148 @default.
• W4214825142 cites W2805339558 @default.
• W4214825142 cites W2891729553 @default.
• W4214825142 cites W2908864375 @default.
• W4214825142 cites W2911360931 @default.
• W4214825142 cites W2945895254 @default.
• W4214825142 cites W2946510248 @default.
• W4214825142 cites W2969337627 @default.
• W4214825142 cites W2991518823 @default.
• W4214825142 cites W3008824480 @default.
• W4214825142 cites W3026969764 @default.
• W4214825142 cites W3040931731 @default.
• W4214825142 cites W3044660945 @default.
• W4214825142 cites W3094965993 @default.
• W4214825142 cites W3110293181 @default.
• W4214825142 cites W3155984011 @default.
• W4214825142 cites W3159456120 @default.
• W4214825142 cites W3164381762 @default.
• W4214825142 cites W3172002638 @default.
• W4214825142 cites W3176018789 @default.
• W4214825142 cites W3198512815 @default.
• W4214825142 doi "https://doi.org/10.3389/fnhum.2022.818711" @default.
• W4214825142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35308615" @default.
• W4214825142 hasPublicationYear "2022" @default.
• W4214825142 type Work @default.
• W4214825142 citedByCount "2" @default.
• W4214825142 countsByYear W42148251422023 @default.
• W4214825142 crossrefType "journal-article" @default.
• W4214825142 hasAuthorship W4214825142A5021933478 @default.

• next