FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214838034> ?p ?o ?g. }

• W4214838034 endingPage "51441" @default.
• W4214838034 startingPage "51427" @default.
• W4214838034 abstract "Abstract The present study was done to evaluate the protective and therapeutic role of mango pulp ( M ), eprosartan drug ( E ), and their co-administration ( EM ) against hepatotoxicity induced by thioacetamide ( T ). Seven groups of rats were prepared as follows: the control (C) group (normal rats), T group (the rats were injected with T), T-M group (the rats were injected with T, and then treated with M), T-E group (the rats were injected with T, and then treated with E), T-EM group (the rats were injected with T, and then treated with E and M), M-TM-M group (the rats were administered with M before, during, and after T injection), and M group (the healthy rats were administered with M only). Firstly, the characterizations of M were determined. Also, the markers of hepatic oxidative stress [malondialdehyde (MDA) and glutathione (GSH) levels and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GSR)], inflammation and fibrosis [(tumor necrosis factor-α (TNF-α) and platelet-derived growth factor-BB (PDGF-BB) levels and gene expression of transforming growth factor-beta1(TGF-β 1 )], and liver functions and microscopic examination were evaluated. The present results revealed that M contains 419 ± 1.04 μg total phenolics as gallic acid equivalent and 6.8 ± 0.05 μg total flavonoids as quercetin equivalent. The analysis of phenolics and flavonoids showed the presence of chlorogenic, caffeic, 2,5-dihydroxy benzoic, 3,5-dicaffeoylquinic, 4,5-dicaffeoylquinic, tannic, cinnamic acidS, and catechin, phloridzin, and quercetin with different concentrations. Also, M contains various minerals with different concentrations involving potassium, calcium, magnesium, sodium, iron, copper, zinc, and manganese. The current results showed that the total antioxidant capacity of 1 g of M was 117.2 ± 1.16 as μg ascorbic acid equivalent. Our biochemical studies showed that all treatments significantly reduced T-induced hepatotoxicity and liver injuries, as the oxidative stress and inflammatory and fibrotic markers were diminished where MDA level and the activities of GST, GSSG, and GR were decreased when compared with T group. In contrast, GSH level and the activities of SOD and GPx and GSH/GSSG ratio were increased. In addition, TNF-α and PDGF-BB levels were reduced, and the gene expression of TGF-β1 was down-regulated. Consequently, the liver functions were significantly improved. In conclusion , each E , M , and EM has a therapeutic effect against T-induced hepatotoxicity via the reduction of the OS, inflammation, and fibrosis. Unfortunately, treatment with M and E simultaneously revealed the less effectiveness than the treatment with M or E demonstrates the presence of anti-synergistic effect between them. Additionally, M-TM-M treatment showed a better effect than T-M treatment against T-induced hepatotoxicity revealing the prophylactic role of M . The administration of healthy rats with M for 12 weeks has no side effect. Graphical abstract" @default.
• W4214838034 created "2022-03-05" @default.
• W4214838034 creator A5014442950 @default.
• W4214838034 creator A5028428275 @default.
• W4214838034 creator A5028927800 @default.
• W4214838034 creator A5029301673 @default.
• W4214838034 creator A5048164887 @default.
• W4214838034 creator A5068433424 @default.
• W4214838034 date "2022-03-04" @default.
• W4214838034 modified "2023-10-18" @default.
• W4214838034 title "Protective and therapeutic role of mango pulp and eprosartan drug and their anti-synergistic effects against thioacetamide-induced hepatotoxicity in male rats" @default.
• W4214838034 cites W1485863792 @default.
• W4214838034 cites W1506043065 @default.
• W4214838034 cites W1554188337 @default.
• W4214838034 cites W1581414347 @default.
• W4214838034 cites W1878803901 @default.
• W4214838034 cites W1962285927 @default.
• W4214838034 cites W1964612391 @default.
• W4214838034 cites W1966502485 @default.
• W4214838034 cites W1983310681 @default.
• W4214838034 cites W1990959547 @default.
• W4214838034 cites W1992195166 @default.
• W4214838034 cites W2002358638 @default.
• W4214838034 cites W2003729005 @default.
• W4214838034 cites W2011207510 @default.
• W4214838034 cites W2020348663 @default.
• W4214838034 cites W2021736637 @default.
• W4214838034 cites W2023536393 @default.
• W4214838034 cites W2025719222 @default.
• W4214838034 cites W2040379693 @default.
• W4214838034 cites W2041169237 @default.
• W4214838034 cites W2043427064 @default.
• W4214838034 cites W2048041008 @default.
• W4214838034 cites W2048612060 @default.
• W4214838034 cites W2050485801 @default.
• W4214838034 cites W2062429989 @default.
• W4214838034 cites W2063576996 @default.
• W4214838034 cites W2068550713 @default.
• W4214838034 cites W2073976519 @default.
• W4214838034 cites W2074687883 @default.
• W4214838034 cites W2077013120 @default.
• W4214838034 cites W2077643311 @default.
• W4214838034 cites W2084299658 @default.
• W4214838034 cites W2094787536 @default.
• W4214838034 cites W2099326493 @default.
• W4214838034 cites W2101518804 @default.
• W4214838034 cites W2107277218 @default.
• W4214838034 cites W2109659566 @default.
• W4214838034 cites W2133341428 @default.
• W4214838034 cites W2141861192 @default.
• W4214838034 cites W2145762359 @default.
• W4214838034 cites W2156239773 @default.
• W4214838034 cites W2161654999 @default.
• W4214838034 cites W2192080449 @default.
• W4214838034 cites W2197332903 @default.
• W4214838034 cites W2227824378 @default.
• W4214838034 cites W2263023695 @default.
• W4214838034 cites W2332311228 @default.
• W4214838034 cites W2335540894 @default.
• W4214838034 cites W2346644876 @default.
• W4214838034 cites W2411139832 @default.
• W4214838034 cites W2413663742 @default.
• W4214838034 cites W2420126765 @default.
• W4214838034 cites W2489690826 @default.
• W4214838034 cites W2510746414 @default.
• W4214838034 cites W2550976409 @default.
• W4214838034 cites W2589145606 @default.
• W4214838034 cites W2590342997 @default.
• W4214838034 cites W2592338368 @default.
• W4214838034 cites W2610502245 @default.
• W4214838034 cites W2778708337 @default.
• W4214838034 cites W2791758888 @default.
• W4214838034 cites W2806295635 @default.
• W4214838034 cites W3082203961 @default.
• W4214838034 cites W3118815068 @default.
• W4214838034 cites W3137205269 @default.
• W4214838034 cites W3163679531 @default.
• W4214838034 cites W3207716923 @default.
• W4214838034 cites W886827392 @default.
• W4214838034 doi "https://doi.org/10.1007/s11356-022-19383-9" @default.
• W4214838034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35244847" @default.
• W4214838034 hasPublicationYear "2022" @default.
• W4214838034 type Work @default.
• W4214838034 citedByCount "6" @default.
• W4214838034 countsByYear W42148380342022 @default.
• W4214838034 countsByYear W42148380342023 @default.
• W4214838034 crossrefType "journal-article" @default.
• W4214838034 hasAuthorship W4214838034A5014442950 @default.
• W4214838034 hasAuthorship W4214838034A5028428275 @default.
• W4214838034 hasAuthorship W4214838034A5028927800 @default.
• W4214838034 hasAuthorship W4214838034A5029301673 @default.
• W4214838034 hasAuthorship W4214838034A5048164887 @default.
• W4214838034 hasAuthorship W4214838034A5068433424 @default.
• W4214838034 hasBestOaLocation W42148380341 @default.
• W4214838034 hasConcept C165069038 @default.
• W4214838034 hasConcept C181199279 @default.
• W4214838034 hasConcept C185592680 @default.
• W4214838034 hasConcept C2775838275 @default.

• next