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- W4214838085 abstract "<ns4:p>Background: Coronavirus disease 2019 (COVID-19) is a global pandemic. Coagulopathy is one of the most common complications characterized by increased D-dimer level. We aimed to investigate the dose-response relationship between elevated D-dimer level and mortality in critically ill COVID-19 patients.</ns4:p><ns4:p> Methods: This was a retrospective observational study in 259 critically ill COVID-19 patients requiring intensive care unit admission between March and December 2020. We compared the mortality rate between patients with and without elevated D-dimer. Receiver operating characteristic (ROC) curve analysis, Fagan’s nomogram, and dose-response relationship were performed to determine the association between D-dimer level and mortality.</ns4:p><ns4:p> Results: Overall mortality rate was 40.9% (106 patients). Median D-dimer level was higher in non-survivor group (10,170 ng/mL vs 4,050 ng/mL, p=0.028). The association remained significant after multivariate logistic regression analysis (p=0.046). The optimal cut-off for D-dimer level to predict mortality from ROC curve analysis was 9,020 ng/mL (OR (odds ratio) 3.73 [95% CI (confidence interval) 1.91 – 7.28], p<0.001). D-dimer level >9,020 ng/mL confers 67% posterior probability of mortality and D-dimer level <9,020 ng/mL had 35% probability of mortality.</ns4:p><ns4:p> Conclusions: There was a non-linear dose-response relationship between D-dimer level and mortality with P<ns4:sub>nonlinearity</ns4:sub> of 0.004. D-dimer level was associated with mortality in critically ill COVID-19 patients in the non-linear dose-response relationship.</ns4:p>" @default.
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- W4214838085 date "2022-03-03" @default.
- W4214838085 modified "2023-09-25" @default.
- W4214838085 title "Dose response relationship between D-dimer level and mortality in critically ill COVID-19 patients: a retrospective observational study" @default.
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- W4214838085 doi "https://doi.org/10.12688/f1000research.108972.1" @default.
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