Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214845044> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4214845044 endingPage "1095" @default.
- W4214845044 startingPage "1093" @default.
- W4214845044 abstract "Repeated injections or infusion of hematopoietic growth factors, such as interleukin-3 (IL-3), granulocyte macrophage-colony stimulating factor (GM-CSF), or granulocyte-colony stimulating factor (G-CSF), accelerate restoration of hematopoiesis in animals compromised by sublethal doses of cytotoxic drugs or irradiation. Previous work by the investigators has shown that IL-1 induced circulating CSF in normal mice and, when used after sublethal irradiation, accelerated the recovery of endogenous splenic colonies. Therefore, IL-1, as well as IFN-gamma, tumor necrosis factor (TNF), G-CSF, and GM-CSF, were evaluated as potential therapeutic agents in irradiated C3H-HeN mice. A single intraperitoneal injection, administered within three hours after a lethal dose (LD)95/30 of irradiation that would kill 95% of mice within 30 days, protected in a dose-dependent manner up to 100% of mice from radiation-induced death due to hematopoietic syndrome. Significant therapeutic effects were also achieved with a single dose of IFN-gamma or of TNF. In contrast, GM-CSF and G-CSF, administered shortly after irradiation, had no effect in the doses used on mice survival." @default.
- W4214845044 created "2022-03-05" @default.
- W4214845044 creator A5055697785 @default.
- W4214845044 creator A5064696208 @default.
- W4214845044 date "1988-09-01" @default.
- W4214845044 modified "2023-10-09" @default.
- W4214845044 title "Cytokines in therapy of radiation injury" @default.
- W4214845044 doi "https://doi.org/10.1182/blood.v72.3.1093.bloodjournal7231093" @default.
- W4214845044 hasPublicationYear "1988" @default.
- W4214845044 type Work @default.
- W4214845044 citedByCount "71" @default.
- W4214845044 countsByYear W42148450442012 @default.
- W4214845044 countsByYear W42148450442013 @default.
- W4214845044 countsByYear W42148450442014 @default.
- W4214845044 countsByYear W42148450442015 @default.
- W4214845044 countsByYear W42148450442019 @default.
- W4214845044 countsByYear W42148450442022 @default.
- W4214845044 crossrefType "journal-article" @default.
- W4214845044 hasAuthorship W4214845044A5055697785 @default.
- W4214845044 hasAuthorship W4214845044A5064696208 @default.
- W4214845044 hasBestOaLocation W42148450441 @default.
- W4214845044 hasConcept C109159458 @default.
- W4214845044 hasConcept C126322002 @default.
- W4214845044 hasConcept C17991360 @default.
- W4214845044 hasConcept C203014093 @default.
- W4214845044 hasConcept C2776694085 @default.
- W4214845044 hasConcept C2777478134 @default.
- W4214845044 hasConcept C2777544843 @default.
- W4214845044 hasConcept C2777767877 @default.
- W4214845044 hasConcept C2777983669 @default.
- W4214845044 hasConcept C2778690821 @default.
- W4214845044 hasConcept C2779958370 @default.
- W4214845044 hasConcept C28328180 @default.
- W4214845044 hasConcept C33070731 @default.
- W4214845044 hasConcept C54355233 @default.
- W4214845044 hasConcept C71924100 @default.
- W4214845044 hasConcept C86803240 @default.
- W4214845044 hasConcept C98274493 @default.
- W4214845044 hasConceptScore W4214845044C109159458 @default.
- W4214845044 hasConceptScore W4214845044C126322002 @default.
- W4214845044 hasConceptScore W4214845044C17991360 @default.
- W4214845044 hasConceptScore W4214845044C203014093 @default.
- W4214845044 hasConceptScore W4214845044C2776694085 @default.
- W4214845044 hasConceptScore W4214845044C2777478134 @default.
- W4214845044 hasConceptScore W4214845044C2777544843 @default.
- W4214845044 hasConceptScore W4214845044C2777767877 @default.
- W4214845044 hasConceptScore W4214845044C2777983669 @default.
- W4214845044 hasConceptScore W4214845044C2778690821 @default.
- W4214845044 hasConceptScore W4214845044C2779958370 @default.
- W4214845044 hasConceptScore W4214845044C28328180 @default.
- W4214845044 hasConceptScore W4214845044C33070731 @default.
- W4214845044 hasConceptScore W4214845044C54355233 @default.
- W4214845044 hasConceptScore W4214845044C71924100 @default.
- W4214845044 hasConceptScore W4214845044C86803240 @default.
- W4214845044 hasConceptScore W4214845044C98274493 @default.
- W4214845044 hasIssue "3" @default.
- W4214845044 hasLocation W42148450441 @default.
- W4214845044 hasOpenAccess W4214845044 @default.
- W4214845044 hasPrimaryLocation W42148450441 @default.
- W4214845044 hasRelatedWork W1971678782 @default.
- W4214845044 hasRelatedWork W2106803404 @default.
- W4214845044 hasRelatedWork W2289550765 @default.
- W4214845044 hasRelatedWork W2314217129 @default.
- W4214845044 hasRelatedWork W2327090652 @default.
- W4214845044 hasRelatedWork W2330558238 @default.
- W4214845044 hasRelatedWork W2384564719 @default.
- W4214845044 hasRelatedWork W2399166583 @default.
- W4214845044 hasRelatedWork W2412257018 @default.
- W4214845044 hasRelatedWork W2415446877 @default.
- W4214845044 hasVolume "72" @default.
- W4214845044 isParatext "false" @default.
- W4214845044 isRetracted "false" @default.
- W4214845044 workType "article" @default.