Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214851353> ?p ?o ?g. }
- W4214851353 abstract "Lymphocytic choriomeningitis virus (LCMV) is a rodent-borne zoonotic arenavirus that causes congenital abnormalities and can be fatal for transplant recipients. Using a genome-wide loss-of-function screen, we identify host factors required for LCMV entry into cells. We identify the lysosomal mucin CD164, glycosylation factors, the heparan sulfate biosynthesis machinery, and the known receptor alpha-dystroglycan (α-DG). Biochemical analysis revealed that the LCMV glycoprotein binds CD164 at acidic pH and requires a sialylated glycan at residue N104. We demonstrate that LCMV entry proceeds by the virus switching binding from heparan sulfate or α-DG at the plasma membrane to CD164 prior to membrane fusion, thus identifying additional potential targets for therapeutic intervention." @default.
- W4214851353 created "2022-03-05" @default.
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- W4214851353 date "2022-03-02" @default.
- W4214851353 modified "2023-09-30" @default.
- W4214851353 title "CD164 is a host factor for lymphocytic choriomeningitis virus entry" @default.
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- W4214851353 doi "https://doi.org/10.1073/pnas.2119676119" @default.
- W4214851353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35235462" @default.
- W4214851353 hasPublicationYear "2022" @default.
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