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- W4214857564 abstract "The hunt for effective vaccines against the major helminth diseases of humans has yet to bear fruit despite much effort over several decades. No individual parasite antigen has proved to elicit full protective immunity, suggesting that combinatorial strategies may be required. Recently it has been discovered that extracellular vesicles released by parasitic helminths contain multiple potential immune modulators, which could together be targeted by a future vaccine. Increasing knowledge of helminth extracellular vesicle components, both enclosed by and exposed on the membrane, will open up a new field of targets for an effective vaccine. This review discusses the interactions between helminth extracellular vesicles and the immune system discovered thus far, and the advantages of targeting these lipid-bound packages with a vaccine. In addition, we also comment upon specific antigens that may be the best targets for an anti-helminth vaccine. In the future, extensive knowledge of the parasites' full arsenal in controlling their host may finally provide us with the ideal target for a fully effective vaccine.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. PMID: 32659278 Funding information This work was supported by: Wellcome Trust, United Kingdom Grant ID: 104111 Wellcome Trust, United Kingdom Grant ID: 106122" @default.
- W4214857564 created "2022-03-05" @default.
- W4214857564 creator A5005421775 @default.
- W4214857564 creator A5075686703 @default.
- W4214857564 date "2021-01-25" @default.
- W4214857564 modified "2023-09-27" @default.
- W4214857564 title "Faculty Opinions recommendation of Extracellular vesicles: new targets for vaccines against helminth parasites." @default.
- W4214857564 doi "https://doi.org/10.3410/f.738322652.793582175" @default.
- W4214857564 hasPublicationYear "2021" @default.
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