FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214857568> ?p ?o ?g. }

• W4214857568 endingPage "1562" @default.
• W4214857568 startingPage "1551" @default.
• W4214857568 abstract "The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)-induced apoptosis and oxidative damage in FLK-BLV cells. The results showed that BPA reduced cell viability in a dose- and time-dependent manner, caused cell shrinkage and induced oxidative stress and apoptosis in FLK-BLV cells, which were effectively reversed by melatonin. In addition, BPA caused autophagy flux impairment, which was confirmed by the increased of LC3-II and p62 levels, whereas melatonin treatment effectively reduced p62 levels under BPA treatment, and reversed apoptosis-related protein expression patterns caused by BPA. However, inhibition of autophagy by CQ partially abolished the protective effect of melatonin on apoptosis, suggesting that melatonin against BPA-induced oxidative injury and apoptosis by activating autophagy pathway. Moreover, we found that melatonin inhibited BPA-induced the activation of p38 MAPK, which was comparable to SB203580 pretreatment, and companied by the activation of autophagy and decreases of apoptosis when compared to BPA alone, indicating that melatonin protected against BPA-induced apoptosis partially through the p38 MAPK-autophagy pathway. In conclusion, these results suggest that melatonin may prevent BPA-induced FLK-BLV cell damage by inhibiting p38/MAPK signaling pathway and activating autophagy, and it could be a potential therapeutic compound in preventing BPA-induced cell damage." @default.
• W4214857568 created "2022-03-05" @default.
• W4214857568 creator A5003632285 @default.
• W4214857568 creator A5022387395 @default.
• W4214857568 creator A5024761740 @default.
• W4214857568 creator A5036670094 @default.
• W4214857568 creator A5046214153 @default.
• W4214857568 creator A5051433397 @default.
• W4214857568 creator A5060470951 @default.
• W4214857568 creator A5075703251 @default.
• W4214857568 creator A5081267522 @default.
• W4214857568 date "2022-03-03" @default.
• W4214857568 modified "2023-10-17" @default.
• W4214857568 title "Melatonin improves bisphenol A‐induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 <scp>MAPK</scp> signaling pathway in <scp>FLK‐BLV</scp> cells" @default.
• W4214857568 cites W1970358298 @default.
• W4214857568 cites W1995987420 @default.
• W4214857568 cites W2031661979 @default.
• W4214857568 cites W2078764376 @default.
• W4214857568 cites W2082967353 @default.
• W4214857568 cites W2083911670 @default.
• W4214857568 cites W2159754384 @default.
• W4214857568 cites W2260102190 @default.
• W4214857568 cites W2493863175 @default.
• W4214857568 cites W2510495333 @default.
• W4214857568 cites W2511585516 @default.
• W4214857568 cites W2514302550 @default.
• W4214857568 cites W2519786994 @default.
• W4214857568 cites W2581392984 @default.
• W4214857568 cites W2592949936 @default.
• W4214857568 cites W2771959358 @default.
• W4214857568 cites W2789559284 @default.
• W4214857568 cites W2791951513 @default.
• W4214857568 cites W2803954431 @default.
• W4214857568 cites W2866751656 @default.
• W4214857568 cites W2885911766 @default.
• W4214857568 cites W2888734518 @default.
• W4214857568 cites W2899406387 @default.
• W4214857568 cites W2910369498 @default.
• W4214857568 cites W2953318228 @default.
• W4214857568 cites W2968419931 @default.
• W4214857568 cites W3004784150 @default.
• W4214857568 cites W3014367181 @default.
• W4214857568 cites W3043990280 @default.
• W4214857568 cites W3047500825 @default.
• W4214857568 cites W3049692965 @default.
• W4214857568 cites W3091554002 @default.
• W4214857568 cites W3092498513 @default.
• W4214857568 cites W3112215634 @default.
• W4214857568 cites W3124322042 @default.
• W4214857568 cites W3177222769 @default.
• W4214857568 cites W3193575398 @default.
• W4214857568 doi "https://doi.org/10.1002/tox.23505" @default.
• W4214857568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35238458" @default.
• W4214857568 hasPublicationYear "2022" @default.
• W4214857568 type Work @default.
• W4214857568 citedByCount "10" @default.
• W4214857568 countsByYear W42148575682022 @default.
• W4214857568 countsByYear W42148575682023 @default.
• W4214857568 crossrefType "journal-article" @default.
• W4214857568 hasAuthorship W4214857568A5003632285 @default.
• W4214857568 hasAuthorship W4214857568A5022387395 @default.
• W4214857568 hasAuthorship W4214857568A5024761740 @default.
• W4214857568 hasAuthorship W4214857568A5036670094 @default.
• W4214857568 hasAuthorship W4214857568A5046214153 @default.
• W4214857568 hasAuthorship W4214857568A5051433397 @default.
• W4214857568 hasAuthorship W4214857568A5060470951 @default.
• W4214857568 hasAuthorship W4214857568A5075703251 @default.
• W4214857568 hasAuthorship W4214857568A5081267522 @default.
• W4214857568 hasConcept C134018914 @default.
• W4214857568 hasConcept C185592680 @default.
• W4214857568 hasConcept C190283241 @default.
• W4214857568 hasConcept C203522944 @default.
• W4214857568 hasConcept C2776151105 @default.
• W4214857568 hasConcept C2778182776 @default.
• W4214857568 hasConcept C31573885 @default.
• W4214857568 hasConcept C51551487 @default.
• W4214857568 hasConcept C53227056 @default.
• W4214857568 hasConcept C55493867 @default.
• W4214857568 hasConcept C57074206 @default.
• W4214857568 hasConcept C62478195 @default.
• W4214857568 hasConcept C86803240 @default.
• W4214857568 hasConcept C95444343 @default.
• W4214857568 hasConceptScore W4214857568C134018914 @default.
• W4214857568 hasConceptScore W4214857568C185592680 @default.
• W4214857568 hasConceptScore W4214857568C190283241 @default.
• W4214857568 hasConceptScore W4214857568C203522944 @default.
• W4214857568 hasConceptScore W4214857568C2776151105 @default.
• W4214857568 hasConceptScore W4214857568C2778182776 @default.
• W4214857568 hasConceptScore W4214857568C31573885 @default.
• W4214857568 hasConceptScore W4214857568C51551487 @default.
• W4214857568 hasConceptScore W4214857568C53227056 @default.
• W4214857568 hasConceptScore W4214857568C55493867 @default.
• W4214857568 hasConceptScore W4214857568C57074206 @default.
• W4214857568 hasConceptScore W4214857568C62478195 @default.
• W4214857568 hasConceptScore W4214857568C86803240 @default.
• W4214857568 hasConceptScore W4214857568C95444343 @default.
• W4214857568 hasFunder F4320321001 @default.
• W4214857568 hasIssue "7" @default.

• next