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- W4214865382 endingPage "321" @default.
- W4214865382 startingPage "309" @default.
- W4214865382 abstract "Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that support germinal centers in producing high-affinity antibody-secreting and memory B cells in mammals and birds. Therefore, mechanisms have evolved to control the life and death of TFH cells for balanced humoral immunity. Recent studies have collectively revealed at least two programmed cell death pathways, ferroptosis and pyroptosis, which govern TFH cell survival under diverse physiopathological conditions including immunization, infection, gut homeostasis, and autoimmunity. We review major recent advances in our understanding of the context-dependent regulation of TFH cell survival via cell death pathways that are closely connected with cellular metabolism. Such knowledge might be applied to inform new strategies aimed at modulating humoral immunity, potentially including enhancement of vaccine efficacies." @default.
- W4214865382 created "2022-03-05" @default.
- W4214865382 creator A5038560506 @default.
- W4214865382 creator A5041339388 @default.
- W4214865382 creator A5060952797 @default.
- W4214865382 creator A5080702153 @default.
- W4214865382 date "2022-04-01" @default.
- W4214865382 modified "2023-10-02" @default.
- W4214865382 title "Context-dependent regulation of follicular helper T cell survival" @default.
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