Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214872122> ?p ?o ?g. }
- W4214872122 abstract "Abstract Chronic methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many neuropsychiatric disorders that is produced by altered balance of local excitatory and inhibitory synaptic transmission. However, there is a dearth of information regarding the cellular and synaptic mechanisms underlying METH-induced cognitive deficits and associated hypofrontal states. We find here that repeated METH administration in rats produces deficits in working memory and increases in inhibitory synaptic transmission onto pyramidal neurons in the prefrontal cortex (PFC). The increased PFC inhibition is detected by an increase in spontaneous and evoked inhibitory postsynaptic synaptic currents (IPSCs), an increase in GABAergic presynaptic function, and a shift in the excitatory-inhibitory balance onto PFC deep-layer pyramidal neurons. We find that pharmacological blockade of D1 dopamine receptor function reduces the METH-induced augmentation of IPSCs, suggesting a critical role for D1 dopamine signaling in METH-induced hypofrontality. In addition, chronic METH administration increases the intrinsic excitability of parvalbumin-positive interneurons, a key local interneuron population in PFC that controls inhibitory tone. Using a cell type-specific chemogenetic approach, we show that increasing PV+FSI activity in the PFC is necessary and sufficient for METH-induced deficits in temporal order memory. Together, our findings reveal that chronic METH exposure increases PFC inhibitory tone through a D1 dopamine signaling-dependent potentiation of inhibitory synaptic transmission, and that reduction of PV+FSI activity can rescue METH-induced cognitive deficits, suggesting a potential therapeutic approach to treating cognitive symptoms in patients suffering from methamphetamine use disorder." @default.
- W4214872122 created "2022-03-05" @default.
- W4214872122 creator A5021887669 @default.
- W4214872122 creator A5055266788 @default.
- W4214872122 creator A5068367310 @default.
- W4214872122 creator A5073972574 @default.
- W4214872122 creator A5088625435 @default.
- W4214872122 date "2022-03-02" @default.
- W4214872122 modified "2023-09-27" @default.
- W4214872122 title "Chronic methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex" @default.
- W4214872122 cites W1488629723 @default.
- W4214872122 cites W1606923904 @default.
- W4214872122 cites W1892194563 @default.
- W4214872122 cites W1921182138 @default.
- W4214872122 cites W1934970405 @default.
- W4214872122 cites W1968073393 @default.
- W4214872122 cites W1975187563 @default.
- W4214872122 cites W1976111950 @default.
- W4214872122 cites W1977177901 @default.
- W4214872122 cites W1977380428 @default.
- W4214872122 cites W1982399538 @default.
- W4214872122 cites W1986411734 @default.
- W4214872122 cites W1987964047 @default.
- W4214872122 cites W1995751463 @default.
- W4214872122 cites W1997953085 @default.
- W4214872122 cites W2001126265 @default.
- W4214872122 cites W2004034476 @default.
- W4214872122 cites W2005063713 @default.
- W4214872122 cites W2007859385 @default.
- W4214872122 cites W2010189130 @default.
- W4214872122 cites W2012211432 @default.
- W4214872122 cites W2014350866 @default.
- W4214872122 cites W2019016101 @default.
- W4214872122 cites W2025603247 @default.
- W4214872122 cites W2031534534 @default.
- W4214872122 cites W2033043582 @default.
- W4214872122 cites W2033923862 @default.
- W4214872122 cites W2034965090 @default.
- W4214872122 cites W2043941998 @default.
- W4214872122 cites W2049245225 @default.
- W4214872122 cites W2050193254 @default.
- W4214872122 cites W2058929671 @default.
- W4214872122 cites W2061833498 @default.
- W4214872122 cites W2065029573 @default.
- W4214872122 cites W2066497867 @default.
- W4214872122 cites W2070900790 @default.
- W4214872122 cites W2078530990 @default.
- W4214872122 cites W2080162167 @default.
- W4214872122 cites W2082352870 @default.
- W4214872122 cites W2085739435 @default.
- W4214872122 cites W2086428786 @default.
- W4214872122 cites W2095056606 @default.
- W4214872122 cites W2095060637 @default.
- W4214872122 cites W2102001229 @default.
- W4214872122 cites W2113475616 @default.
- W4214872122 cites W2119856466 @default.
- W4214872122 cites W2120077675 @default.
- W4214872122 cites W2121166877 @default.
- W4214872122 cites W2125776807 @default.
- W4214872122 cites W2131379141 @default.
- W4214872122 cites W2132622783 @default.
- W4214872122 cites W2133956528 @default.
- W4214872122 cites W2136550122 @default.
- W4214872122 cites W2144223409 @default.
- W4214872122 cites W2147761349 @default.
- W4214872122 cites W2147970286 @default.
- W4214872122 cites W2151137320 @default.
- W4214872122 cites W2156780983 @default.
- W4214872122 cites W2157084876 @default.
- W4214872122 cites W2167375169 @default.
- W4214872122 cites W2170328434 @default.
- W4214872122 cites W2170814877 @default.
- W4214872122 cites W2229724869 @default.
- W4214872122 cites W2408679814 @default.
- W4214872122 cites W2485545500 @default.
- W4214872122 cites W2549366107 @default.
- W4214872122 cites W2586292647 @default.
- W4214872122 cites W2599116301 @default.
- W4214872122 cites W2600363486 @default.
- W4214872122 cites W2607724497 @default.
- W4214872122 cites W2756956075 @default.
- W4214872122 cites W2774489697 @default.
- W4214872122 cites W2793050579 @default.
- W4214872122 cites W2809042666 @default.
- W4214872122 cites W2886055476 @default.
- W4214872122 cites W2914179938 @default.
- W4214872122 cites W2926410262 @default.
- W4214872122 cites W2933289315 @default.
- W4214872122 cites W2948457966 @default.
- W4214872122 cites W2952959359 @default.
- W4214872122 cites W3013281916 @default.
- W4214872122 cites W3014918858 @default.
- W4214872122 cites W3044343625 @default.
- W4214872122 doi "https://doi.org/10.1101/2022.02.28.482382" @default.
- W4214872122 hasPublicationYear "2022" @default.
- W4214872122 type Work @default.
- W4214872122 citedByCount "0" @default.
- W4214872122 crossrefType "posted-content" @default.
- W4214872122 hasAuthorship W4214872122A5021887669 @default.
- W4214872122 hasAuthorship W4214872122A5055266788 @default.