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- W4214872281 abstract "Abstract Background: Multilocus sequence typing (MLST) act as an accurate approach to characterize bacterial population genetics, phylogeny and epidemiology, and has not yet been applied to Klebsiella aerogenes. Results: A MLST scheme was established for a collection of 213 isolates of K. aerogenes. These strains exhibited considerable sequence diversity under purifying selection, and could be assigned into 135 sequence types, which were further divided into 8 clonal complexes and a lot of doubletons and singletons scatterred in the population snapshot. Five separately clustering lineages were presented in the population, which displayed evident homologous recombination occurred within and across lineages, with a tendency of linkage disequilibrium. Conclusions: K. aerogenes shows an epidemic population structure displaying high levels of recombination occurring more frequently than point mutation. Key words: Klebsiella aerogenes; multilocus sequence typing; sequence types; purifying selection; linkage disequilibrium; population structure" @default.
- W4214872281 created "2022-03-05" @default.
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- W4214872281 date "2019-08-21" @default.
- W4214872281 modified "2023-10-18" @default.
- W4214872281 title "Epidemic population structure of clinical Klebsiella aerogenes inferred by multilocus sequence typing" @default.
- W4214872281 doi "https://doi.org/10.21203/rs.2.13267/v1" @default.
- W4214872281 hasPublicationYear "2019" @default.
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