FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214883979> ?p ?o ?g. }

• W4214883979 abstract "Objective The random urine protein-to-creatinine ratio (UPCR) is a screening test used for predicting clinically significant proteinuria (urine protein ≥ 300 mg) during pregnancy. No consensus exists on the optimal random UPCR cutoff for performing follow-up 24 hour urine (24H) total protein collection. We aim to evaluate the test performance of random UPCR in predicting proteinuria in a contemporary cohort. Study Design This was a retrospective cohort study of pregnant patients at our institution from 2014 to 2018 with a random UPCR and follow-up 24H protein collection. The primary analysis estimated the test characteristics (sensitivity, specificity, positive and negative predictive values) of using random UPCR for the detection of proteinuria defined as urine protein ≥300 mg on 24H protein collection. UPCR cutoffs from 0.10 to 0.30 mg/dL were evaluated, receiver operator characteristic (ROC) curve was constructed, and area under the curve (AUC) was determined. A secondary analysis examined the correlation between UPCR and 24H protein using least squares regression and Pearson correlation. Results Paired UPCR and 24H collection results were available for 1,120 patients. Mean gestational age at time of UPCR was 31.1 ± 5.1 weeks and 687 (61.3%) of patients had a 24H ≥300 mg. UPCR <0.10 mg/dL effectively excluded proteinuria ≥300 mg on 24H collection, while UPCR ≥0.18 mg/dL correctly classifies proteinuria with 91% sensitivity, 57% specificity, 77% positive predictive value, and 79% negative predictive value. UPCR ≥1.07 mg/dL had 100% specificity for 24 hour proteinuria. The area under ROC curve was 0.86. UPCR and 24H collection were highly correlated with a Pearson correlation coefficient of 0.85. After our institution lowered the threshold to obtain a 24H from UPCR ≥0.20 mg/dL to ≥0.10 mg/dL in May 2017, the percentage of patients meeting criteria for 24H collection increased from 57.8 to 84.4%. Conclusion The AUC and Pearson correlation suggest random UPCR is a high performance test for the prediction of proteinuria on 24H. Optimal test performance is dependent upon clinical consideration and upon the implications of the disease or condition. A random UPCR screen positive threshold of 0.18 mg/dL maximizes sensitivity to identify clinically significant proteinuria. Key Points" @default.
• W4214883979 created "2022-03-05" @default.
• W4214883979 creator A5004502545 @default.
• W4214883979 creator A5011543303 @default.
• W4214883979 creator A5038869001 @default.
• W4214883979 creator A5052256934 @default.
• W4214883979 creator A5058349686 @default.
• W4214883979 creator A5065100402 @default.
• W4214883979 creator A5083435931 @default.
• W4214883979 creator A5087552412 @default.
• W4214883979 creator A5090539153 @default.
• W4214883979 creator A5090966165 @default.
• W4214883979 date "2022-03-03" @default.
• W4214883979 modified "2023-09-22" @default.
• W4214883979 title "Contemporary Test Performance of the Random Urine Protein-to-creatinine Ratio" @default.
• W4214883979 cites W1963765713 @default.
• W4214883979 cites W1966089692 @default.
• W4214883979 cites W1979119639 @default.
• W4214883979 cites W2010052445 @default.
• W4214883979 cites W2034440477 @default.
• W4214883979 cites W2036477553 @default.
• W4214883979 cites W2107456031 @default.
• W4214883979 cites W2156490188 @default.
• W4214883979 cites W2157381327 @default.
• W4214883979 cites W2161817495 @default.
• W4214883979 cites W2289644546 @default.
• W4214883979 cites W2460054597 @default.
• W4214883979 cites W2640870849 @default.
• W4214883979 cites W3160565403 @default.
• W4214883979 doi "https://doi.org/10.1055/a-1786-8847" @default.
• W4214883979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35240698" @default.
• W4214883979 hasPublicationYear "2022" @default.
• W4214883979 type Work @default.
• W4214883979 citedByCount "0" @default.
• W4214883979 crossrefType "journal-article" @default.
• W4214883979 hasAuthorship W4214883979A5004502545 @default.
• W4214883979 hasAuthorship W4214883979A5011543303 @default.
• W4214883979 hasAuthorship W4214883979A5038869001 @default.
• W4214883979 hasAuthorship W4214883979A5052256934 @default.
• W4214883979 hasAuthorship W4214883979A5058349686 @default.
• W4214883979 hasAuthorship W4214883979A5065100402 @default.
• W4214883979 hasAuthorship W4214883979A5083435931 @default.
• W4214883979 hasAuthorship W4214883979A5087552412 @default.
• W4214883979 hasAuthorship W4214883979A5090539153 @default.
• W4214883979 hasAuthorship W4214883979A5090966165 @default.
• W4214883979 hasConcept C121332964 @default.
• W4214883979 hasConcept C126322002 @default.
• W4214883979 hasConcept C126894567 @default.
• W4214883979 hasConcept C2777218350 @default.
• W4214883979 hasConcept C2778217198 @default.
• W4214883979 hasConcept C2779234561 @default.
• W4214883979 hasConcept C2779561371 @default.
• W4214883979 hasConcept C2780026642 @default.
• W4214883979 hasConcept C2780091579 @default.
• W4214883979 hasConcept C2780306776 @default.
• W4214883979 hasConcept C54355233 @default.
• W4214883979 hasConcept C58471807 @default.
• W4214883979 hasConcept C62520636 @default.
• W4214883979 hasConcept C71924100 @default.
• W4214883979 hasConcept C76318530 @default.
• W4214883979 hasConcept C86803240 @default.
• W4214883979 hasConceptScore W4214883979C121332964 @default.
• W4214883979 hasConceptScore W4214883979C126322002 @default.
• W4214883979 hasConceptScore W4214883979C126894567 @default.
• W4214883979 hasConceptScore W4214883979C2777218350 @default.
• W4214883979 hasConceptScore W4214883979C2778217198 @default.
• W4214883979 hasConceptScore W4214883979C2779234561 @default.
• W4214883979 hasConceptScore W4214883979C2779561371 @default.
• W4214883979 hasConceptScore W4214883979C2780026642 @default.
• W4214883979 hasConceptScore W4214883979C2780091579 @default.
• W4214883979 hasConceptScore W4214883979C2780306776 @default.
• W4214883979 hasConceptScore W4214883979C54355233 @default.
• W4214883979 hasConceptScore W4214883979C58471807 @default.
• W4214883979 hasConceptScore W4214883979C62520636 @default.
• W4214883979 hasConceptScore W4214883979C71924100 @default.
• W4214883979 hasConceptScore W4214883979C76318530 @default.
• W4214883979 hasConceptScore W4214883979C86803240 @default.
• W4214883979 hasLocation W42148839791 @default.
• W4214883979 hasLocation W42148839792 @default.
• W4214883979 hasOpenAccess W4214883979 @default.
• W4214883979 hasPrimaryLocation W42148839791 @default.
• W4214883979 hasRelatedWork W1968416042 @default.
• W4214883979 hasRelatedWork W1990535018 @default.
• W4214883979 hasRelatedWork W1996237000 @default.
• W4214883979 hasRelatedWork W2335031361 @default.
• W4214883979 hasRelatedWork W2546638189 @default.
• W4214883979 hasRelatedWork W2801363206 @default.
• W4214883979 hasRelatedWork W3155613242 @default.
• W4214883979 hasRelatedWork W4252701451 @default.
• W4214883979 hasRelatedWork W82105127 @default.
• W4214883979 hasRelatedWork W2088864129 @default.
• W4214883979 isParatext "false" @default.
• W4214883979 isRetracted "false" @default.
• W4214883979 workType "article" @default.