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- W4214885557 endingPage "267" @default.
- W4214885557 startingPage "255" @default.
- W4214885557 abstract "As of February 2022, SARS-CoV-2 is still one of the most serious public health threats due to its high mortality rate and rapid spread of novel variants. Since the first outbreak in 2019, general understanding of SARS-CoV-2 has been improved through basic and clinical studies; however, knowledge gaps still exist in our understanding of the emerging novel SARSCoV-2 variants, which impacts the corresponding development of vaccines and therapeutics. Especially, accumulation of mutations in SARS-CoV-2 and rapid spread in populations with previous immunity has resulted in selection of variants that evade the host immune response. This phenomenon threatens to render current SARS-CoV-2 vaccines ineffective for controlling the pandemic. Proper animal models are essential for detailed investigations into the viral etiology, transmission and pathogenesis mechanisms, as well as evaluation of the efficacy of vaccine candidates against recent SARS-CoV-2 variants. Further, the choice of animal model for each research topic is important for researchers to gain better knowledge of recent SARS-CoV-2 variants. Here, we review the advantages and limitations of each animal model, including mice, hamsters, ferrets, and non-human primates, to elucidate variant SARS-CoV-2 etiology and transmission and to evaluate therapeutic and vaccine efficacy." @default.
- W4214885557 created "2022-03-05" @default.
- W4214885557 creator A5022146096 @default.
- W4214885557 creator A5044972915 @default.
- W4214885557 creator A5059886221 @default.
- W4214885557 date "2022-03-01" @default.
- W4214885557 modified "2023-09-24" @default.
- W4214885557 title "Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models" @default.
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