FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214887561> ?p ?o ?g. }

• W4214887561 endingPage "1270" @default.
• W4214887561 startingPage "1257" @default.
• W4214887561 abstract "Objective Systemic juvenile idiopathic arthritis (JIA) is a systemic inflammatory disease with childhood onset. Systemic JIA is associated with neutrophilia, including immature granulocytes, potentially driven by the growth factor granulocyte‐colony stimulating factor (G‐CSF). This study was undertaken to investigate the role of G‐CSF in the pathology of systemic JIA. Methods Injection of Freund's complete adjuvant (CFA) in BALB/c mice induces mild inflammation and neutrophilia in wild‐type (WT) mice and a more pronounced disease, reminiscent to that of JIA patients, in interferon‐γ–knockout (IFNγ‐KO) mice. Extramedullary myelopoiesis was studied in CFA‐immunized mice by single‐cell RNA sequencing, and the effect of G‐CSF receptor (G‐CSFR) blockage on neutrophil development and systemic JIA pathology was evaluated. Additionally, plasma G‐CSF levels were measured in patients. Results Both in systemic JIA patients and in a corresponding mouse model, plasma G‐CSF levels were increased. In the mouse model, we demonstrated that G‐CSF is responsible for the observed neutrophilia and extramedullary myelopoiesis and the induction of immature neutrophils and myeloid‐derived suppressor‐like cells. Administration of a G‐CSFR antagonizing antibody blocked the maturation and differentiation of neutrophils in CFA‐immunized mice. In IFNγ‐KO mice, treatment was associated with almost complete inhibition of arthritis due to reduced neutrophilia and osteoclast formation. Disease symptoms were ameliorated, but slight increases in interleukin‐6 (IL‐6), tumor necrosis factor, and IL‐17 were detected upon G‐CSFR inhibition in the IFNγ‐KO mice, and were associated with mild increases in weight loss, tail damage, and immature red blood cells. Conclusion We describe the role of G‐CSF in a mouse model of systemic JIA and suggest an important role for G‐CSF–induced myelopoiesis and neutrophilia in regulating the development of arthritis." @default.
• W4214887561 created "2022-03-05" @default.
• W4214887561 creator A5006394234 @default.
• W4214887561 creator A5010441434 @default.
• W4214887561 creator A5011820553 @default.
• W4214887561 creator A5012712033 @default.
• W4214887561 creator A5029211157 @default.
• W4214887561 creator A5033360879 @default.
• W4214887561 creator A5048612586 @default.
• W4214887561 creator A5053441669 @default.
• W4214887561 creator A5067567986 @default.
• W4214887561 creator A5071793915 @default.
• W4214887561 creator A5078760536 @default.
• W4214887561 creator A5080119252 @default.
• W4214887561 creator A5080857315 @default.
• W4214887561 creator A5081418446 @default.
• W4214887561 creator A5081665848 @default.
• W4214887561 creator A5082974246 @default.
• W4214887561 date "2022-05-31" @default.
• W4214887561 modified "2023-10-15" @default.
• W4214887561 title "Role for Granulocyte <scp>Colony‐Stimulating</scp> Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis" @default.
• W4214887561 cites W1592057209 @default.
• W4214887561 cites W1784973049 @default.
• W4214887561 cites W1931386434 @default.
• W4214887561 cites W1981127449 @default.
• W4214887561 cites W1987842727 @default.
• W4214887561 cites W1989111278 @default.
• W4214887561 cites W2004638361 @default.
• W4214887561 cites W2010387075 @default.
• W4214887561 cites W2036054943 @default.
• W4214887561 cites W2040174427 @default.
• W4214887561 cites W2040937550 @default.
• W4214887561 cites W2044748328 @default.
• W4214887561 cites W2047904172 @default.
• W4214887561 cites W2051611327 @default.
• W4214887561 cites W2058874539 @default.
• W4214887561 cites W2064282763 @default.
• W4214887561 cites W2076096572 @default.
• W4214887561 cites W2083548960 @default.
• W4214887561 cites W2106781193 @default.
• W4214887561 cites W2109666345 @default.
• W4214887561 cites W2111421688 @default.
• W4214887561 cites W2148594394 @default.
• W4214887561 cites W2317865868 @default.
• W4214887561 cites W2479329805 @default.
• W4214887561 cites W2529259537 @default.
• W4214887561 cites W2548228770 @default.
• W4214887561 cites W2597316994 @default.
• W4214887561 cites W2615089059 @default.
• W4214887561 cites W2616023745 @default.
• W4214887561 cites W2695567167 @default.
• W4214887561 cites W2775642644 @default.
• W4214887561 cites W2787894829 @default.
• W4214887561 cites W2793468273 @default.
• W4214887561 cites W2892591675 @default.
• W4214887561 cites W2899318740 @default.
• W4214887561 cites W2904625821 @default.
• W4214887561 cites W2914524806 @default.
• W4214887561 cites W2915104822 @default.
• W4214887561 cites W2953177296 @default.
• W4214887561 cites W2955003667 @default.
• W4214887561 cites W3007604420 @default.
• W4214887561 cites W3015471778 @default.
• W4214887561 cites W3016724352 @default.
• W4214887561 cites W3044190151 @default.
• W4214887561 cites W3093916434 @default.
• W4214887561 cites W3162485228 @default.
• W4214887561 cites W4211253912 @default.
• W4214887561 cites W4252438878 @default.
• W4214887561 cites W4255497843 @default.
• W4214887561 cites W4313335081 @default.
• W4214887561 doi "https://doi.org/10.1002/art.42104" @default.
• W4214887561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35243819" @default.
• W4214887561 hasPublicationYear "2022" @default.
• W4214887561 type Work @default.
• W4214887561 citedByCount "5" @default.
• W4214887561 countsByYear W42148875612022 @default.
• W4214887561 countsByYear W42148875612023 @default.
• W4214887561 crossrefType "journal-article" @default.
• W4214887561 hasAuthorship W4214887561A5006394234 @default.
• W4214887561 hasAuthorship W4214887561A5010441434 @default.
• W4214887561 hasAuthorship W4214887561A5011820553 @default.
• W4214887561 hasAuthorship W4214887561A5012712033 @default.
• W4214887561 hasAuthorship W4214887561A5029211157 @default.
• W4214887561 hasAuthorship W4214887561A5033360879 @default.
• W4214887561 hasAuthorship W4214887561A5048612586 @default.
• W4214887561 hasAuthorship W4214887561A5053441669 @default.
• W4214887561 hasAuthorship W4214887561A5067567986 @default.
• W4214887561 hasAuthorship W4214887561A5071793915 @default.
• W4214887561 hasAuthorship W4214887561A5078760536 @default.
• W4214887561 hasAuthorship W4214887561A5080119252 @default.
• W4214887561 hasAuthorship W4214887561A5080857315 @default.
• W4214887561 hasAuthorship W4214887561A5081418446 @default.
• W4214887561 hasAuthorship W4214887561A5081665848 @default.
• W4214887561 hasAuthorship W4214887561A5082974246 @default.
• W4214887561 hasBestOaLocation W42148875612 @default.
• W4214887561 hasConcept C109159458 @default.
• W4214887561 hasConcept C126322002 @default.

• next