FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214889728> ?p ?o ?g. }

• W4214889728 endingPage "932.e7" @default.
• W4214889728 startingPage "920" @default.
• W4214889728 abstract "IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection biology. However, the mechanistic relationships between IDO1 in amino acid depletion versus product generation have remained a longstanding mystery. We found an unrecognized link between IDO1 and cell survival mediated by KYN that serves as the source for molecules that inhibit ferroptotic cell death. We show that this effect requires KYN export from IDO1-expressing cells, which is then available for non-IDO1-expressing cells via SLC7A11, the central transporter involved in ferroptosis suppression. Whether inside the producer IDO1+ cell or the receiver cell, KYN is converted into downstream metabolites, suppressing ferroptosis by ROS scavenging and activating an NRF2-dependent, AHR-independent cell-protective pathway, including SLC7A11, propagating anti-ferroptotic signaling. IDO1, therefore, controls a multi-pronged protection pathway from ferroptotic cell death, underscoring the need to re-evaluate the use of IDO1 inhibitors in cancer treatment." @default.
• W4214889728 created "2022-03-05" @default.
• W4214889728 creator A5006044247 @default.
• W4214889728 creator A5017714497 @default.
• W4214889728 creator A5019030969 @default.
• W4214889728 creator A5022666503 @default.
• W4214889728 creator A5022968869 @default.
• W4214889728 creator A5053313863 @default.
• W4214889728 creator A5056004646 @default.
• W4214889728 creator A5057445390 @default.
• W4214889728 creator A5070000759 @default.
• W4214889728 creator A5082576583 @default.
• W4214889728 date "2022-03-01" @default.
• W4214889728 modified "2023-10-09" @default.
• W4214889728 title "Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling" @default.
• W4214889728 cites W1613701641 @default.
• W4214889728 cites W1973251492 @default.
• W4214889728 cites W1974401900 @default.
• W4214889728 cites W1982789056 @default.
• W4214889728 cites W1996005089 @default.
• W4214889728 cites W1997183854 @default.
• W4214889728 cites W1998142996 @default.
• W4214889728 cites W2008343182 @default.
• W4214889728 cites W2029149797 @default.
• W4214889728 cites W2045171661 @default.
• W4214889728 cites W2052787011 @default.
• W4214889728 cites W2092524794 @default.
• W4214889728 cites W2110905563 @default.
• W4214889728 cites W2133972226 @default.
• W4214889728 cites W2138207763 @default.
• W4214889728 cites W2152239989 @default.
• W4214889728 cites W2163294546 @default.
• W4214889728 cites W2169456326 @default.
• W4214889728 cites W2472071085 @default.
• W4214889728 cites W2506191144 @default.
• W4214889728 cites W2762087180 @default.
• W4214889728 cites W2767055857 @default.
• W4214889728 cites W2790897054 @default.
• W4214889728 cites W2797244941 @default.
• W4214889728 cites W2805022017 @default.
• W4214889728 cites W2884856991 @default.
• W4214889728 cites W2899358783 @default.
• W4214889728 cites W2901765784 @default.
• W4214889728 cites W2942397792 @default.
• W4214889728 cites W2943793201 @default.
• W4214889728 cites W2949375297 @default.
• W4214889728 cites W2950983102 @default.
• W4214889728 cites W2955990162 @default.
• W4214889728 cites W2957105318 @default.
• W4214889728 cites W2989750739 @default.
• W4214889728 cites W3019679086 @default.
• W4214889728 cites W3034060092 @default.
• W4214889728 cites W3037778440 @default.
• W4214889728 cites W3081988080 @default.
• W4214889728 cites W3087782427 @default.
• W4214889728 cites W3089174202 @default.
• W4214889728 cites W3108493784 @default.
• W4214889728 cites W3118244505 @default.
• W4214889728 cites W3129929910 @default.
• W4214889728 cites W3133721962 @default.
• W4214889728 cites W3135675512 @default.
• W4214889728 cites W3142536378 @default.
• W4214889728 cites W3146146998 @default.
• W4214889728 cites W3160103368 @default.
• W4214889728 cites W4200237452 @default.
• W4214889728 doi "https://doi.org/10.1016/j.molcel.2022.02.007" @default.
• W4214889728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35245456" @default.
• W4214889728 hasPublicationYear "2022" @default.
• W4214889728 type Work @default.
• W4214889728 citedByCount "24" @default.
• W4214889728 countsByYear W42148897282022 @default.
• W4214889728 countsByYear W42148897282023 @default.
• W4214889728 crossrefType "journal-article" @default.
• W4214889728 hasAuthorship W4214889728A5006044247 @default.
• W4214889728 hasAuthorship W4214889728A5017714497 @default.
• W4214889728 hasAuthorship W4214889728A5019030969 @default.
• W4214889728 hasAuthorship W4214889728A5022666503 @default.
• W4214889728 hasAuthorship W4214889728A5022968869 @default.
• W4214889728 hasAuthorship W4214889728A5053313863 @default.
• W4214889728 hasAuthorship W4214889728A5056004646 @default.
• W4214889728 hasAuthorship W4214889728A5057445390 @default.
• W4214889728 hasAuthorship W4214889728A5070000759 @default.
• W4214889728 hasAuthorship W4214889728A5082576583 @default.
• W4214889728 hasBestOaLocation W42148897281 @default.
• W4214889728 hasConcept C121608353 @default.
• W4214889728 hasConcept C1491633281 @default.
• W4214889728 hasConcept C150555746 @default.
• W4214889728 hasConcept C190283241 @default.
• W4214889728 hasConcept C2776706248 @default.
• W4214889728 hasConcept C2776710720 @default.
• W4214889728 hasConcept C2777503454 @default.
• W4214889728 hasConcept C31573885 @default.
• W4214889728 hasConcept C515207424 @default.
• W4214889728 hasConcept C54355233 @default.
• W4214889728 hasConcept C55493867 @default.
• W4214889728 hasConcept C62478195 @default.
• W4214889728 hasConcept C86803240 @default.
• W4214889728 hasConcept C95444343 @default.

• next