Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214891024> ?p ?o ?g. }
- W4214891024 abstract "Colorectal cancer (CRC) is the third most common type of cancer worldwide. Distant metastasis is the major cause of cancer-related mortality in patients with CRC. Epithelial-mesenchymal transition (EMT) is a critical process triggered during tumor metastasis, which is also the main impetus and the essential access within this duration. Therefore, targeting EMT-related molecular pathways has been considered a novel strategy to explore effective therapeutic agents against metastatic CRC. Traditional Chinese medicines (TCMs) with unique properties multi-target and multi-link that exert their therapeutic efficacies holistically, which could inhibit the invasion and metastasis ability of CRC cells via inhibiting the EMT process by down-regulating transforming growth factor-β (TGF-β)/Smads, PI3K/Akt, NF-κB, Wnt/β-catenin, and Notch signaling pathways. The objective of this review is to summarize and assess the anti-metastatic effect of TCM-originated bioactive compounds and Chinese medicine formulas by mediating EMT-associated signaling pathways in CRC therapy, providing a foundation for further research on the exact mechanisms of action through which TCMs affect EMT transform in CRC." @default.
- W4214891024 created "2022-03-05" @default.
- W4214891024 creator A5017360203 @default.
- W4214891024 creator A5030764071 @default.
- W4214891024 creator A5039055312 @default.
- W4214891024 creator A5049176770 @default.
- W4214891024 creator A5049812619 @default.
- W4214891024 creator A5057688632 @default.
- W4214891024 creator A5061353154 @default.
- W4214891024 creator A5080106817 @default.
- W4214891024 date "2022-03-04" @default.
- W4214891024 modified "2023-10-18" @default.
- W4214891024 title "Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms" @default.
- W4214891024 cites W1185768747 @default.
- W4214891024 cites W1587073068 @default.
- W4214891024 cites W1849856438 @default.
- W4214891024 cites W1920639967 @default.
- W4214891024 cites W1928327536 @default.
- W4214891024 cites W1943317391 @default.
- W4214891024 cites W1963501822 @default.
- W4214891024 cites W1964081206 @default.
- W4214891024 cites W1964847767 @default.
- W4214891024 cites W1976359234 @default.
- W4214891024 cites W1978940759 @default.
- W4214891024 cites W1980457341 @default.
- W4214891024 cites W1987616149 @default.
- W4214891024 cites W1991472423 @default.
- W4214891024 cites W2010039799 @default.
- W4214891024 cites W2016526517 @default.
- W4214891024 cites W2018855427 @default.
- W4214891024 cites W2029908111 @default.
- W4214891024 cites W2042008402 @default.
- W4214891024 cites W2044045650 @default.
- W4214891024 cites W2045136333 @default.
- W4214891024 cites W2054423272 @default.
- W4214891024 cites W2055021348 @default.
- W4214891024 cites W2068718097 @default.
- W4214891024 cites W2076092843 @default.
- W4214891024 cites W2088380495 @default.
- W4214891024 cites W2092180337 @default.
- W4214891024 cites W2097681338 @default.
- W4214891024 cites W2102707911 @default.
- W4214891024 cites W2164015122 @default.
- W4214891024 cites W2164561943 @default.
- W4214891024 cites W2277818594 @default.
- W4214891024 cites W2296094448 @default.
- W4214891024 cites W2297295275 @default.
- W4214891024 cites W2302003756 @default.
- W4214891024 cites W2333951227 @default.
- W4214891024 cites W2358496802 @default.
- W4214891024 cites W2397712813 @default.
- W4214891024 cites W2417275289 @default.
- W4214891024 cites W2463009484 @default.
- W4214891024 cites W2463615816 @default.
- W4214891024 cites W2469004374 @default.
- W4214891024 cites W2482793089 @default.
- W4214891024 cites W2500192509 @default.
- W4214891024 cites W2517160621 @default.
- W4214891024 cites W2522813771 @default.
- W4214891024 cites W2529267350 @default.
- W4214891024 cites W2529945898 @default.
- W4214891024 cites W2530860431 @default.
- W4214891024 cites W2532677926 @default.
- W4214891024 cites W2539374591 @default.
- W4214891024 cites W2559966901 @default.
- W4214891024 cites W2560728740 @default.
- W4214891024 cites W2564001275 @default.
- W4214891024 cites W2572807235 @default.
- W4214891024 cites W2573073131 @default.
- W4214891024 cites W2586407709 @default.
- W4214891024 cites W2588938963 @default.
- W4214891024 cites W2592457325 @default.
- W4214891024 cites W2594618686 @default.
- W4214891024 cites W2595529112 @default.
- W4214891024 cites W2595834232 @default.
- W4214891024 cites W2597922397 @default.
- W4214891024 cites W2604636580 @default.
- W4214891024 cites W2611480249 @default.
- W4214891024 cites W2621577071 @default.
- W4214891024 cites W2624281215 @default.
- W4214891024 cites W2734283649 @default.
- W4214891024 cites W2742349536 @default.
- W4214891024 cites W2745798279 @default.
- W4214891024 cites W2755129520 @default.
- W4214891024 cites W2757830262 @default.
- W4214891024 cites W2760803612 @default.
- W4214891024 cites W2763410913 @default.
- W4214891024 cites W2766237346 @default.
- W4214891024 cites W2766272386 @default.
- W4214891024 cites W2770348692 @default.
- W4214891024 cites W2771654374 @default.
- W4214891024 cites W2773598187 @default.
- W4214891024 cites W2782675598 @default.
- W4214891024 cites W2783686102 @default.
- W4214891024 cites W2786843484 @default.
- W4214891024 cites W2790436045 @default.
- W4214891024 cites W2790628964 @default.
- W4214891024 cites W2790991175 @default.
- W4214891024 cites W2792971491 @default.
- W4214891024 cites W2794199180 @default.