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- W4214891120 endingPage "1553" @default.
- W4214891120 startingPage "1545" @default.
- W4214891120 abstract "Influenza is an acute respiratory infectious disease caused by influenza virus, leading to huge morbidity and mortality in humans worldwide. Despite the availability of antivirals in the clinic, the emergence of resistant strains calls for antivirals with novel mechanisms of action. The PB2 subunit of the influenza A virus polymerase is a promising target because of its vital role in the 'cap-snatching' mechanism. In this review, we summarize the technologies and medicinal chemistry strategies for hit identification, hit-to-lead and lead-to-candidate optimization, and current challenges in PB2 inhibitor development, as well as offering insights for the fight against drug resistance." @default.
- W4214891120 created "2022-03-05" @default.
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- W4214891120 date "2022-06-01" @default.
- W4214891120 modified "2023-09-24" @default.
- W4214891120 title "Approaches for discovery of small-molecular antivirals targeting to influenza A virus PB2 subunit" @default.
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- W4214891120 doi "https://doi.org/10.1016/j.drudis.2022.02.024" @default.
- W4214891120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35247593" @default.
- W4214891120 hasPublicationYear "2022" @default.
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