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- W4214893520 abstract "Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal region of mRNAs and then scan to the initiation codon to form 48S initiation complexes with established codon-anticodon base-pairing. Stress-activated phosphorylation of eIF2alpha reduces the level of active eIF2, globally inhibiting translation. However, translation of several viral mRNAs, including Sindbis virus (SV) 26S mRNA and mRNAs containing hepatitis C virus (HCV)-like IRESs, is wholly or partially resistant to inhibition by eIF2 phosphorylation, despite requiring Met-tRNA(Met)(i). Here we report the identification of related proteins that individually (Ligatin) or together (the oncogene MCT-1 and DENR, which are homologous to N-terminal and C-terminal regions of Ligatin, respectively) promote efficient eIF2-independent recruitment of Met-tRNA(Met)(i) to 40S/mRNA complexes, if attachment of 40S subunits to the mRNA places the initiation codon directly in the P site, as on HCV-like IRESs and, as we show here, SV 26S mRNA. In addition to their role in initiation, Ligatin and MCT-1/DENR can promote release of deacylated tRNA and mRNA from recycled 40S subunits after ABCE1-mediated dissociation of post-termination ribosomes. PMID: 20713520 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R01 GM080623 NIGMS NIH HHS, United States Grant ID: R01 GM059660 NIAID NIH HHS, United States Grant ID: R01 AI051340-08 NIAID NIH HHS, United States Grant ID: R01 AI051340 NIGMS NIH HHS, United States Grant ID: GM80623 NIGMS NIH HHS, United States Grant ID: GM59660 NIAID NIH HHS, United States Grant ID: AI51340 More Less keyboard_arrow_down" @default.
- W4214893520 created "2022-03-05" @default.
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- W4214893520 date "2010-10-06" @default.
- W4214893520 modified "2023-09-28" @default.
- W4214893520 title "Faculty Opinions recommendation of Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling." @default.
- W4214893520 doi "https://doi.org/10.3410/f.5505960.5474058" @default.
- W4214893520 hasPublicationYear "2010" @default.
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