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- W4214893607 abstract "To examine the vestibulo-ocular reflex (VOR) and compensatory-saccades before and after complete unilateral vestibular deafferentation (UVD).Forty patients were studied before and after surgery for vestibular or facial schwannoma using the video head-impulse test (vHIT) and multivariable regression.Prior to UVD (median(IQR), 14(58.4) days), the average VOR-gain towards the lesioned-ear was lower than in normal for all semicircular canals (lateral, anterior, posterior: 0.69, 0.72, 0.49). One-week after UVD (5(3.0) days) VOR gains were further reduced (0.22, 0.37, 0.27), however, within one-year after UVD (171(125.0) days) the lesioned-ear VOR gains had slightly increased (+0.08, +0.11, +0.03), maximally for the anterior-canal. After UVD, the VOR gain asymmetry (gain towards minus away from intact-ear) was lower for the intact posterior-canal plane (0.56, 0.56, 0.22). For the lesioned canals, the frequency and amplitude of the first compensatory-saccade increased from 61-93% and 1.9-3.6° pre-surgery, to 98-99% and to 3.1-5.9° one-week post-surgery and remained unchanged over one-year; second saccade frequency and amplitude decreased over the same timespan.After UVD the high-acceleration VOR for the intact posterior-canal plane is more symmetrical than the other canals. First compensatory-saccades adapt within one week and subsequently change only marginally.Saccade compensation from surgical UVD is near complete by one-week." @default.
- W4214893607 created "2022-03-05" @default.
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- W4214893607 date "2022-06-01" @default.
- W4214893607 modified "2023-10-17" @default.
- W4214893607 title "The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section" @default.
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- W4214893607 doi "https://doi.org/10.1016/j.clinph.2022.02.014" @default.
- W4214893607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35370080" @default.