FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214894967> ?p ?o ?g. }

• W4214894967 endingPage "121634" @default.
• W4214894967 startingPage "121634" @default.
• W4214894967 abstract "Chronic inflammation is a significant pathological process found in a range of disease states. Treatments to reduce inflammation in this family of diseases may improve symptoms and disease progression, but are largely limited by variable response rates, cost, and off-target effects. Macrophages are implicated in many inflammatory diseases for their critical role in the maintenance and resolution of inflammation. Macrophages exhibit significant plasticity to direct the inflammatory response by taking on an array of pro- and anti-inflammatory phenotypes based on extracellular cues. In this work, a nanoparticle has been developed to target sites of inflammation and reduce the inflammatory macrophage phenotype by mimicking the anti-inflammatory effect of apoptotic cell engulfment. The nanoparticle, comprised of a poly(lactide-co-glycolide) core, is coated with phosphatidylserine (PS)-supplemented cell plasma membrane to emulate key characteristics of the apoptotic cell surface. The particle surface is additionally functionalized with an acid-sensitive sheddable polyethylene glycol (PEG) moiety to increase the delivery of the nanoparticles to low pH environments such as those of chronic inflammation. In a mouse model of lipopolysaccharide-induced inflammation, particles were preferentially taken up by macrophages at the site and promoted an anti-inflammatory phenotype shift. This PEGylated membrane coating increased the delivery of nanoparticles to sites of inflammation and may be used as a tool alone or as a delivery scheme for additional cargo to reduce macrophage-associated inflammatory response." @default.
• W4214894967 created "2022-03-05" @default.
• W4214894967 creator A5001188798 @default.
• W4214894967 creator A5049102689 @default.
• W4214894967 creator A5059612667 @default.
• W4214894967 creator A5070865261 @default.
• W4214894967 creator A5072806966 @default.
• W4214894967 creator A5073997385 @default.
• W4214894967 creator A5087576156 @default.
• W4214894967 date "2022-04-01" @default.
• W4214894967 modified "2023-09-26" @default.
• W4214894967 title "Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift" @default.
• W4214894967 cites W1522182824 @default.
• W4214894967 cites W1843302206 @default.
• W4214894967 cites W1940692702 @default.
• W4214894967 cites W1965623612 @default.
• W4214894967 cites W1977648439 @default.
• W4214894967 cites W1982096781 @default.
• W4214894967 cites W1984617964 @default.
• W4214894967 cites W1998182735 @default.
• W4214894967 cites W2001435521 @default.
• W4214894967 cites W2004057177 @default.
• W4214894967 cites W2008317548 @default.
• W4214894967 cites W2010621614 @default.
• W4214894967 cites W2020466729 @default.
• W4214894967 cites W2020794186 @default.
• W4214894967 cites W2032654453 @default.
• W4214894967 cites W2039930764 @default.
• W4214894967 cites W2087821065 @default.
• W4214894967 cites W2089900609 @default.
• W4214894967 cites W2092699829 @default.
• W4214894967 cites W2123251003 @default.
• W4214894967 cites W2135550210 @default.
• W4214894967 cites W2149026148 @default.
• W4214894967 cites W2151181789 @default.
• W4214894967 cites W2156368993 @default.
• W4214894967 cites W2159001825 @default.
• W4214894967 cites W2169027813 @default.
• W4214894967 cites W2412889589 @default.
• W4214894967 cites W2490023827 @default.
• W4214894967 cites W2539871382 @default.
• W4214894967 cites W2554835169 @default.
• W4214894967 cites W2588130687 @default.
• W4214894967 cites W2801577951 @default.
• W4214894967 cites W2807299013 @default.
• W4214894967 cites W2890781138 @default.
• W4214894967 cites W2893229678 @default.
• W4214894967 cites W3014325962 @default.
• W4214894967 cites W3014734085 @default.
• W4214894967 cites W3124037640 @default.
• W4214894967 cites W4235300003 @default.
• W4214894967 cites W4242171500 @default.
• W4214894967 doi "https://doi.org/10.1016/j.ijpharm.2022.121634" @default.
• W4214894967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35247497" @default.
• W4214894967 hasPublicationYear "2022" @default.
• W4214894967 type Work @default.
• W4214894967 citedByCount "4" @default.
• W4214894967 countsByYear W42148949672022 @default.
• W4214894967 countsByYear W42148949672023 @default.
• W4214894967 crossrefType "journal-article" @default.
• W4214894967 hasAuthorship W4214894967A5001188798 @default.
• W4214894967 hasAuthorship W4214894967A5049102689 @default.
• W4214894967 hasAuthorship W4214894967A5059612667 @default.
• W4214894967 hasAuthorship W4214894967A5070865261 @default.
• W4214894967 hasAuthorship W4214894967A5072806966 @default.
• W4214894967 hasAuthorship W4214894967A5073997385 @default.
• W4214894967 hasAuthorship W4214894967A5087576156 @default.
• W4214894967 hasConcept C185592680 @default.
• W4214894967 hasConcept C190283241 @default.
• W4214894967 hasConcept C202751555 @default.
• W4214894967 hasConcept C203014093 @default.
• W4214894967 hasConcept C2776914184 @default.
• W4214894967 hasConcept C2778754761 @default.
• W4214894967 hasConcept C2779244956 @default.
• W4214894967 hasConcept C55493867 @default.
• W4214894967 hasConcept C86803240 @default.
• W4214894967 hasConcept C95444343 @default.
• W4214894967 hasConceptScore W4214894967C185592680 @default.
• W4214894967 hasConceptScore W4214894967C190283241 @default.
• W4214894967 hasConceptScore W4214894967C202751555 @default.
• W4214894967 hasConceptScore W4214894967C203014093 @default.
• W4214894967 hasConceptScore W4214894967C2776914184 @default.
• W4214894967 hasConceptScore W4214894967C2778754761 @default.
• W4214894967 hasConceptScore W4214894967C2779244956 @default.
• W4214894967 hasConceptScore W4214894967C55493867 @default.
• W4214894967 hasConceptScore W4214894967C86803240 @default.
• W4214894967 hasConceptScore W4214894967C95444343 @default.
• W4214894967 hasFunder F4320332161 @default.
• W4214894967 hasLocation W42148949671 @default.
• W4214894967 hasLocation W42148949672 @default.
• W4214894967 hasOpenAccess W4214894967 @default.
• W4214894967 hasPrimaryLocation W42148949671 @default.
• W4214894967 hasRelatedWork W2088218868 @default.
• W4214894967 hasRelatedWork W2386214274 @default.
• W4214894967 hasRelatedWork W2391151592 @default.
• W4214894967 hasRelatedWork W2533674896 @default.
• W4214894967 hasRelatedWork W2766799248 @default.
• W4214894967 hasRelatedWork W2786840192 @default.

• next