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• W4214895895 abstract "By employing the 1,8-naphthylamide as fluorophore and the hydrazine as carbonyl recognition unit (named NH ) for fluorescent derivatization, a simple, rapid and ultrasensitive UHPLC-FLD method has been established for 10 carbonyl species determination within only 8 min. The well explored methodology of developing a novel fluorescent reagent is an optimal good attempt to establish a bridge between fluorophore design and UHPLC-FLD analysis for more molecules. • The NH as a novel fluorescent reagent enables ultrasensitive determination of carbonyl species by UPLC-FLD. • The easy synthesized NH can rapidly respond such as aldehyde, ketone and benzaldehyde with 300-fold fluorescent enhancement. • The transition state calculation under density functional theory (DFT-TS) has revealed the activation energy of 18.81 kcal·mol −1 . • The established UPLC method shows ultralow LODs (1.0 × 10 −12 M) and good linearity (R 2 ≥ 0.999) for 10 carbonyls within only 8 min. Reactive carbonyl species (RCS) are ubiquitous compounds existing in organisms and environment, while the current methods no longer suitable for analysis of instable and violate RCS due to their harsh reaction condition and multistep pretreatment. In this work, a simple, rapid and ultrasensitive UHPLC-FLD method has been established by employing the 1,8-naphthylamide as fluorophore and the hydrazine as carbonyl recognition unit (named NH ) to fluorescent derivatization. The synthesized NH performs expectant 300-fold “off–on” signal with high reactivity to carbonyl species and transition state calculation under density functional theory (DFT-TS) has revealed the activation energy of 18.81 kcal·mol −1 indicating the NH can interact with carbonyls at room temperature. By using the NH as a novel fluorescent reagent, the optimized UHPLC method shows satisfactory precision (RSD ≤ 1.5%) and ultralow LODs (1.0 × 10 −12 M) and good linearity (R 2 ≥ 0.999) for 10 carbonyls within only 8 min. The established method has been successfully applied to analysis RCS in air and organisms, especially, with assistance of manual packing SPE cartridge, the pretreatment of air sampling can be greatly simplified. It is believed that the proposed methodology can become to an effective procedure for developing novel UHPLC-FLD methodology for other analytes." @default.
• W4214895895 created "2022-03-05" @default.
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• W4214895895 date "2022-06-01" @default.
• W4214895895 modified "2023-10-06" @default.
• W4214895895 title "Isopropyl-naphthylamide-hydrazine as a novel fluorescent reagent for ultrasensitive determination of carbonyl species on UPLC" @default.
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• W4214895895 doi "https://doi.org/10.1016/j.microc.2022.107308" @default.
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