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- W4214897373 abstract "Micro-RNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. Many miRNAs regulate cancer pathways, and this makes them attractive therapeutic targets or potential drugs for cancer therapy. Currently, the biggest difficulties that miRNA-based drugs must face before their clinical application are mainly their safety, as they must be specific for their given target; and their delivery, because of RNA fragility and the difficulties on targeting a specific tissue. Although the initial interest in miRNA-based therapies started to fade in the early 2010s, recent successes are reigniting the field. Since 2018, two miRNA-based drugs have been approved by the FDA (patisiran and givosiran), and many more are in preclinical and clinical trials for the treatment of several diseases, including cancer. Concretely, MRX34 (ClinicalTrials.gov Identifier: NCT0182997), cobomarsen (NCT03837457), and targomiRs (NCT02369198) have reached up to phase-II clinical trials for the treatment of advanced solid tumors, mycosis fungoides, and malignant pleural mesothelioma, respectively. Despite some early failures on the development of miRNA therapeutics, several clinical trials involving more miRNA-based drugs are under way, and miRNA-based drugs hold a promising future for specific cancer treatment." @default.
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- W4214897373 date "2022-01-01" @default.
- W4214897373 modified "2023-10-18" @default.
- W4214897373 title "Opportunities of miRNAs in cancer therapeutics" @default.
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- W4214897373 doi "https://doi.org/10.1016/b978-0-12-822287-4.00015-3" @default.
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