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- W4214897436 abstract "Clinical studies suggest that psychedelics exert robust therapeutic benefits in a number of psychiatric conditions including substance use disorder. Preclinical studies focused on safety and efficacy of these compounds are necessary to determine the full range of psychedelics' effects.The present study explores the behavioral pharmacology of structurally distinct psychedelics in paradigms associated with serotonin 2A receptor (5-HT2AR) activation and behavioral disruption in two rodent models. Utilizing the selective 5-HT2AR antagonist volinanserin, we aimed to provide further pharmacological assessment of psychedelic effects in rodents.We compared volinanserin (0.0001-0.1 mg/kg) antagonism of the phenethylamine 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI, 1.0 mg/kg) and the ergoline lysergic acid diethylamide (LSD, 0.32 mg/kg) in preclinical assays predictive of hallucinations (head-twitch response or HTR in mice) and behavioral disruption (intracranial self-stimulation or ICSS in rats). Volinanserin antagonism of the phenethylamine mescaline, the tryptamine psilocybin, and the k-opioid receptor agonist salvinorin A was also evaluated in the rat ICSS assay.Volinanserin had similar potency, effectiveness, and time-course to attenuate DOI-induced HTR in mice and ICSS depression in rats. Volinanserin completely blocked LSD-induced HTR in mice, but not LSD-induced ICSS depression in rats. Volinanserin also reversed ICSS depression by mescaline, but it was only partially effective to reduce the effects of psilocybin, and it exacerbated ICSS depression by salvinorin A.Although hallucination-related HTR behavior induced by phenethylamine, ergoline, and tryptamine psychedelics appears to be 5-HT2AR-mediated, the receptor(s) responsible for behavioral disruptive effects may differ among these three structural classes." @default.
- W4214897436 created "2022-03-05" @default.
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- W4214897436 date "2022-03-02" @default.
- W4214897436 modified "2023-10-15" @default.
- W4214897436 title "Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents" @default.
- W4214897436 cites W1964918564 @default.
- W4214897436 cites W1973613743 @default.
- W4214897436 cites W1976580014 @default.
- W4214897436 cites W1976604434 @default.
- W4214897436 cites W1980453588 @default.
- W4214897436 cites W1988743423 @default.
- W4214897436 cites W1997058647 @default.
- W4214897436 cites W2005643237 @default.
- W4214897436 cites W2009134620 @default.
- W4214897436 cites W2010654991 @default.
- W4214897436 cites W2014120139 @default.
- W4214897436 cites W2015870346 @default.
- W4214897436 cites W2016437478 @default.
- W4214897436 cites W2017187845 @default.
- W4214897436 cites W2020974659 @default.
- W4214897436 cites W2024217117 @default.
- W4214897436 cites W2024942419 @default.
- W4214897436 cites W2035999666 @default.
- W4214897436 cites W2048184801 @default.
- W4214897436 cites W2063426640 @default.
- W4214897436 cites W2065619226 @default.
- W4214897436 cites W2075238613 @default.
- W4214897436 cites W2075776243 @default.
- W4214897436 cites W2076287600 @default.
- W4214897436 cites W2076920165 @default.
- W4214897436 cites W2078821747 @default.
- W4214897436 cites W2079106221 @default.
- W4214897436 cites W2080123927 @default.
- W4214897436 cites W2080974839 @default.
- W4214897436 cites W2087542866 @default.
- W4214897436 cites W2109884356 @default.
- W4214897436 cites W2122150204 @default.
- W4214897436 cites W2122459973 @default.
- W4214897436 cites W2134431067 @default.
- W4214897436 cites W2141611982 @default.
- W4214897436 cites W2154105276 @default.
- W4214897436 cites W2157977435 @default.
- W4214897436 cites W2158474067 @default.
- W4214897436 cites W2166952073 @default.
- W4214897436 cites W2167295928 @default.
- W4214897436 cites W2170585987 @default.
- W4214897436 cites W2171104921 @default.
- W4214897436 cites W2326527053 @default.
- W4214897436 cites W2336055336 @default.
- W4214897436 cites W2396675581 @default.
- W4214897436 cites W2403267016 @default.
- W4214897436 cites W2506717582 @default.
- W4214897436 cites W2516564083 @default.
- W4214897436 cites W2558412547 @default.
- W4214897436 cites W2581696375 @default.
- W4214897436 cites W2590821743 @default.
- W4214897436 cites W2725596576 @default.
- W4214897436 cites W2744640768 @default.
- W4214897436 cites W2808301300 @default.
- W4214897436 cites W2888119399 @default.
- W4214897436 cites W2909121609 @default.
- W4214897436 cites W2950564037 @default.
- W4214897436 cites W2954962259 @default.
- W4214897436 cites W2957937196 @default.
- W4214897436 cites W2979144408 @default.
- W4214897436 cites W2999364864 @default.
- W4214897436 cites W2999684597 @default.
- W4214897436 cites W3003349663 @default.
- W4214897436 cites W3022631502 @default.
- W4214897436 cites W3027810862 @default.
- W4214897436 cites W3112535936 @default.
- W4214897436 cites W3116827302 @default.
- W4214897436 cites W3118717131 @default.
- W4214897436 cites W3155245221 @default.
- W4214897436 cites W3156937150 @default.
- W4214897436 cites W3157088173 @default.
- W4214897436 cites W3179469168 @default.
- W4214897436 cites W3180562559 @default.
- W4214897436 cites W3189055936 @default.
- W4214897436 cites W3205085416 @default.
- W4214897436 cites W4211211437 @default.
- W4214897436 cites W4238102281 @default.
- W4214897436 doi "https://doi.org/10.1007/s00213-022-06092-x" @default.
- W4214897436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35233648" @default.
- W4214897436 hasPublicationYear "2022" @default.
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