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- W4214897776 abstract "Lupus nephritis is a common severe manifestation of systemic lupus erythematosus. Despite recent advances in therapeutics and understanding of its pathogenesis, there are still substantial unmet needs. This review discusses recent discoveries in these areas, especially the role of tubulointerstitial inflammation (TII) in lupus nephritis.Non-white ethnicity is still a major risk and poor prognostic factor in lupus nephritis. TII and fibrosis have been found to be associated with worse renal outcome but the current lupus nephritis treatment guidelines and trials are based on the degree of glomerular inflammation. In combination with mycophenolate mofetil, a B-cell-targeted therapy (belimumab) and a calcineurin inhibitor (voclosporin) have shown efficacy in recent lupus nephritis trials. However, response rates have been modest. While lupus glomerulonephritis results from immune complex deposition derived from systemic autoantibodies, TII arises from complex processes associated with in situ adaptive cell networks. These include local antibody production, and cognate or antigen-induced interactions between T follicular helper cells, and likely other T-cell populations, with antigen presenting cells including B cells, myeloid dendritic cells and plasmacytoid dendritic cells.Better understanding of the pathogenesis of TII will identify novel therapeutic targets predicted to improve outcomes in our patients with lupus nephritis." @default.
- W4214897776 created "2022-03-05" @default.
- W4214897776 creator A5027395645 @default.
- W4214897776 creator A5037428155 @default.
- W4214897776 creator A5043435912 @default.
- W4214897776 date "2020-12-30" @default.
- W4214897776 modified "2023-09-30" @default.
- W4214897776 title "Cellular aspects of the pathogenesis of lupus nephritis" @default.
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- W4214897776 doi "https://doi.org/10.1097/bor.0000000000000777" @default.
- W4214897776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33394604" @default.
- W4214897776 hasPublicationYear "2020" @default.
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