Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214902785> ?p ?o ?g. }
- W4214902785 abstract "Abstract The mechanical properties of the extracellular matrix (ECM) dictate tissue behaviour. In epithelial tissues, laminin is both a very abundant ECM component, and a key supporting element. Here we show that laminin hinders the mechanoresponses of breast epithelial cells by shielding the nucleus from mechanical deformation. Coating substrates with laminin-111, unlike fibronectin or collagen I, impairs cell response to substrate rigidity, and YAP nuclear localization. Blocking the laminin-specific integrin β4 increases nuclear YAP ratios in a rigidity dependent manner, without affecting cell forces or focal adhesions. By combining mechanical perturbations and mathematical modelling, we show that β4 integrins establish a mechanical linkage between the substrate and the keratin cytoskeleton, which stiffens the network and shields the nucleus from actomyosin-mediated mechanical deformation. In turn, this affects nuclear YAP mechanoresponses and chromatin methylation. Our results demonstrate a mechanism by which tissues can regulate their sensitivity to mechanical signals." @default.
- W4214902785 created "2022-03-05" @default.
- W4214902785 creator A5005167860 @default.
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- W4214902785 creator A5064200243 @default.
- W4214902785 date "2022-03-01" @default.
- W4214902785 modified "2023-10-15" @default.
- W4214902785 title "The laminin-keratin link shields the nucleus from mechanical deformation and signalling" @default.
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