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- W4214904080 abstract "Objective To examine the association between depressive symptoms, leukocyte telomere length–a marker of cellular ageing, and survival amongst lung cancer patients.Design Patients with non-small cell lung cancer were recruited from a university-affiliated cancer center clinic.Main Outcome Patients (N = 67) reported on depressive symptoms and provided a blood sample for leukocyte telomere length assessment at baseline and at a 3-month follow-up. Survival status was tracked over 3 years.Results Age at diagnosis and depressive symptoms, as measured by the CES-D, were associated with shorter leukocyte telomere length (p < .05), although only age at diagnosis contributed statistical significance to the model. Depressive symptoms predicted shorter survival from date of diagnosis (p < .01). Patients who reported experiencing clinically meaningful levels of depressive symptoms (CES-D scores ≥ 16) demonstrated shorter survival than those who reported sub-clinical levels of depressive symptoms (p < .05). Leukocyte telomere length did not emerge as a predictor of shorter survival.Conclusion Clinically meaningful levels of depressive symptoms are associated with shorter survival amongst lung cancer patients. These findings support the on-going efforts to screen all cancer patients for low mood and to investigate mechanisms linking depressive symptoms and shorter survival in cancer contexts." @default.
- W4214904080 created "2022-03-05" @default.
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- W4214904080 date "2022-03-03" @default.
- W4214904080 modified "2023-10-18" @default.
- W4214904080 title "Depressive symptoms and shorter survival in lung cancer: the role of leukocyte telomere length" @default.
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- W4214904080 doi "https://doi.org/10.1080/08870446.2022.2040500" @default.
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