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• W4214905674 abstract "Abstract Establishing and maintaining tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing A uto I mmune Re gulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. Within weeks of birth, a separate wave of Treg cell differentiation occurs in the periphery, upon exposure to dietary and commensal microbiota derived antigens, yet the cell types responsible for the generation of peripheral Treg (pTreg) cells are not known. Here we identified a new class of RORγt + antigen-presenting cells (APC), dubbed Thetis cells (TCs), with transcriptional features of both mTECs and dendritic cells (DCs), comprising 4 major sub-groups (TC I-IV). We uncovered a developmental wave of TCs within intestinal lymph nodes during a critical early life window, coincident with the wave of pTreg cell differentiation. While TC I and III expressed the signature mTEC nuclear factor Aire, TC IV lacked Aire expression and were enriched for molecules required for pTreg generation, including the TGF-β activating integrin αvβ8. Loss of either MHCII or Itgb8 expression by TCs led to a profound impairment in intestinal pTreg differentiation, with onset of intestinal inflammation. In contrast, MHCII expression by RORγt + group 3 innate lymphoid cells (ILC3) and classical DCs was neither sufficient nor required for pTreg generation, further implicating TCs as the tolerogenic RORγt + APC with an essential early life function. Our studies reveal parallel pathways for establishment of tolerance to self and foreign antigen within the thymus and periphery, marked by involvement of shared cellular and transcriptional programs." @default.
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• W4214905674 date "2022-03-01" @default.
• W4214905674 modified "2023-09-26" @default.
• W4214905674 title "A novel RORγt⁺ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life" @default.
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• W4214905674 cites W1969868671 @default.
• W4214905674 cites W1970777915 @default.
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• W4214905674 cites W1977761329 @default.
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• W4214905674 cites W2169456326 @default.
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• W4214905674 cites W2266367473 @default.
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• W4214905674 doi "https://doi.org/10.1101/2022.02.26.481148" @default.
• W4214905674 hasPublicationYear "2022" @default.
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