FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214908068> ?p ?o ?g. }

• W4214908068 endingPage "692" @default.
• W4214908068 startingPage "685" @default.
• W4214908068 abstract "To better understand breast cancer etiology and progression, we explored the association between promoter methylation status of three breast cancer-related genes (BRCA1, APC, and p16) and survival in a large cohort of women with breast cancer. About 800 archived tumor tissues were collected from women diagnosed with a first primary invasive or in situ breast cancer in 1996–1997. The vital status of the participants was followed through the end of year 2005 with a mean follow-up time of 8.0 years. Promoter methylation was assessed by methylation-specific PCR (for BRCA1) and MethyLight (for APC and p16). The association of promoter methylation and breast cancer mortality was evaluated by Cox-proportional hazards models. Methylated promoters were found in 59.0, 48.4, and 3.6% of the tumor samples for BRCA1, APC, and p16, respectively. Breast cancer-specific mortality was strongly associated with promoter methylation of p16 [HR and 95% CI: 3.53 (1.83–6.78)], whereas the associations with of BRCA1 and APC were less pronounced [HR and 95% CI: 1.81 (1.18–2.78) and 1.46 (0.98–2.17), respectively]. Similar associations were observed with all-cause mortality. As the number of methylated genes increased, the risk of breast cancer-specific mortality also increased in a dose-dependent manner (P, trend = 0.01). Importantly, even with our results stratified by hormone receptor status, promoter methylation of the three genes remained predictive of mortality. Our results suggest that promoter methylation could be promising epigenetic markers to be considered for breast cancer survival." @default.
• W4214908068 created "2022-03-05" @default.
• W4214908068 creator A5005360514 @default.
• W4214908068 creator A5005623959 @default.
• W4214908068 creator A5018904268 @default.
• W4214908068 creator A5029469326 @default.
• W4214908068 creator A5030084822 @default.
• W4214908068 creator A5057311183 @default.
• W4214908068 creator A5061130250 @default.
• W4214908068 creator A5067322330 @default.
• W4214908068 creator A5072980162 @default.
• W4214908068 creator A5082554584 @default.
• W4214908068 creator A5084377118 @default.
• W4214908068 creator A5084696219 @default.
• W4214908068 date "2009-11-17" @default.
• W4214908068 modified "2023-10-15" @default.
• W4214908068 title "Gene promoter methylation is associated with increased mortality among women with breast cancer" @default.
• W4214908068 cites W1489499258 @default.
• W4214908068 cites W1919063129 @default.
• W4214908068 cites W1947335951 @default.
• W4214908068 cites W1999617682 @default.
• W4214908068 cites W2005038334 @default.
• W4214908068 cites W2015620982 @default.
• W4214908068 cites W2024667952 @default.
• W4214908068 cites W2037207156 @default.
• W4214908068 cites W2041819668 @default.
• W4214908068 cites W2046520696 @default.
• W4214908068 cites W2050376635 @default.
• W4214908068 cites W2068359467 @default.
• W4214908068 cites W2070876263 @default.
• W4214908068 cites W2074605890 @default.
• W4214908068 cites W2081562657 @default.
• W4214908068 cites W2085377566 @default.
• W4214908068 cites W2090049612 @default.
• W4214908068 cites W2095632857 @default.
• W4214908068 cites W2105031531 @default.
• W4214908068 cites W2105428856 @default.
• W4214908068 cites W2107277218 @default.
• W4214908068 cites W2115358481 @default.
• W4214908068 cites W2125473366 @default.
• W4214908068 cites W2135946283 @default.
• W4214908068 cites W2135953007 @default.
• W4214908068 cites W2138178697 @default.
• W4214908068 cites W2143129903 @default.
• W4214908068 cites W2155708732 @default.
• W4214908068 cites W2157027870 @default.
• W4214908068 cites W2245476761 @default.
• W4214908068 doi "https://doi.org/10.1007/s10549-009-0628-2" @default.
• W4214908068 hasPublicationYear "2009" @default.
• W4214908068 type Work @default.
• W4214908068 citedByCount "31" @default.
• W4214908068 countsByYear W42149080682012 @default.
• W4214908068 countsByYear W42149080682013 @default.
• W4214908068 countsByYear W42149080682014 @default.
• W4214908068 countsByYear W42149080682015 @default.
• W4214908068 countsByYear W42149080682016 @default.
• W4214908068 countsByYear W42149080682017 @default.
• W4214908068 countsByYear W42149080682018 @default.
• W4214908068 countsByYear W42149080682019 @default.
• W4214908068 countsByYear W42149080682021 @default.
• W4214908068 countsByYear W42149080682022 @default.
• W4214908068 countsByYear W42149080682023 @default.
• W4214908068 crossrefType "journal-article" @default.
• W4214908068 hasAuthorship W4214908068A5005360514 @default.
• W4214908068 hasAuthorship W4214908068A5005623959 @default.
• W4214908068 hasAuthorship W4214908068A5018904268 @default.
• W4214908068 hasAuthorship W4214908068A5029469326 @default.
• W4214908068 hasAuthorship W4214908068A5030084822 @default.
• W4214908068 hasAuthorship W4214908068A5057311183 @default.
• W4214908068 hasAuthorship W4214908068A5061130250 @default.
• W4214908068 hasAuthorship W4214908068A5067322330 @default.
• W4214908068 hasAuthorship W4214908068A5072980162 @default.
• W4214908068 hasAuthorship W4214908068A5082554584 @default.
• W4214908068 hasAuthorship W4214908068A5084377118 @default.
• W4214908068 hasAuthorship W4214908068A5084696219 @default.
• W4214908068 hasBestOaLocation W42149080682 @default.
• W4214908068 hasConcept C101762097 @default.
• W4214908068 hasConcept C104317684 @default.
• W4214908068 hasConcept C121608353 @default.
• W4214908068 hasConcept C126322002 @default.
• W4214908068 hasConcept C143998085 @default.
• W4214908068 hasConcept C150194340 @default.
• W4214908068 hasConcept C190727270 @default.
• W4214908068 hasConcept C33288867 @default.
• W4214908068 hasConcept C41091548 @default.
• W4214908068 hasConcept C502942594 @default.
• W4214908068 hasConcept C50382708 @default.
• W4214908068 hasConcept C530470458 @default.
• W4214908068 hasConcept C54355233 @default.
• W4214908068 hasConcept C71924100 @default.
• W4214908068 hasConcept C86803240 @default.
• W4214908068 hasConceptScore W4214908068C101762097 @default.
• W4214908068 hasConceptScore W4214908068C104317684 @default.
• W4214908068 hasConceptScore W4214908068C121608353 @default.
• W4214908068 hasConceptScore W4214908068C126322002 @default.
• W4214908068 hasConceptScore W4214908068C143998085 @default.
• W4214908068 hasConceptScore W4214908068C150194340 @default.
• W4214908068 hasConceptScore W4214908068C190727270 @default.

• next