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- W4214909436 abstract "Posttraumatic stress disorder (PTSD) is an acquired, debilitating, psychiatric disorder characterized by functionally deficient physiological and psychological symptoms in the aftermath of a traumatic event. This chapter emphasizes the critical role of pharmacoepigenetics in addressing the interindividual variability seen in patients treated with current medications for trauma- and stress-related neuropsychiatric disorders such as PTSD, and highlights the scarcity of effective drugs for treating the symptoms of patients with these disorders. Chronic PTSD treatment is complicated by comorbid symptomatology, and attempts to suppress traumatic memories, for example, remain difficult. As the epigenome can either modulate drug response or be pharmacologically regulated, we underline the importance of epigenetic-based interventions for alleviating PTSD pathogenesis. We hypothesize that selective epigenetic machinery targeting with epidrugs and/or epinutraceuticals could be a viable strategy to mitigate trauma- and stress-related neuropsychiatric disorders. Furthermore, compelling evidence has linked immune system dysregulation to abnormal neuronal signaling and psychiatric disorders. However, much effort is required to transform and advance our understanding of PTSD and comorbid disorders so that new and innovative interventions for those suffering from this critical neuropsychiatric illness can be developed." @default.
- W4214909436 created "2022-03-05" @default.
- W4214909436 creator A5004538565 @default.
- W4214909436 creator A5073941282 @default.
- W4214909436 creator A5091401644 @default.
- W4214909436 date "2022-01-01" @default.
- W4214909436 modified "2023-09-30" @default.
- W4214909436 title "Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals" @default.
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