FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214915560> ?p ?o ?g. }

• W4214915560 abstract "Abstract Genetic and epigenetic modifications of genes involved in the key regulatory pathways play a significant role in the pathophysiology and progression of multifactorial diseases. The present study is an attempt to identify single nucleotide variations (SNVs) at CpG sites of promoters of ACAT1 , APOB , APOE , CYBA , FAS , FLT1 , KSR2 , LDLR , MMP9 , PCSK9 , PHOX2A , REST , SH2B3 , SORT1 and TIMP1 genes influencing CpG island (CGI) existence and size associated with the pathophysiology of Diabetes mellitus, Coronary artery disease and Cancers. Promoter sequences located between −2000 to + 2000 bp were retrieved from the EPDnew database and predicted the CpG island using MethPrimer. Further, SNVs at CpG sites were accessed from NCBI, Ensembl while transcription factor (TF) binding sites were accessed using AliBaba2.1. CGI existence and size were determined for each SNV at CpG site with respect to wild type and variant allele by MethPrimer. A total of 200 SNVs at CpG sites were analyzed from the promoters of ACAT1 , APOB , APOE , CYBA , FAS , FLT1 , KSR2 , LDLR , MMP9 , PCSK9 , PHOX2A , REST , SH2B3 , SORT1 and TIMP1 genes. Of these, only 17 (8.5%) SNVs were found to influence the loss of CGI while 70 (35%) SNVs were found to reduce the size of CGI. It has also been found that 59% (10) of CGI abolishing SNVs are showing differences in binding of TFs. The findings of the study suggest that the candidate SNVs at CpG sites regulating CGI existence and size might influence the DNA methylation status and expression of genes involved in molecular pathways associated with several diseases. The insights of the present study may pave the way for new experimental studies to undertake challenges in DNA methylation, gene expression and protein assays." @default.
• W4214915560 created "2022-03-05" @default.
• W4214915560 creator A5014250889 @default.
• W4214915560 creator A5016564797 @default.
• W4214915560 creator A5026742937 @default.
• W4214915560 creator A5046737215 @default.
• W4214915560 creator A5064886633 @default.
• W4214915560 creator A5075298426 @default.
• W4214915560 creator A5078435747 @default.
• W4214915560 date "2022-03-04" @default.
• W4214915560 modified "2023-10-16" @default.
• W4214915560 title "In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size" @default.
• W4214915560 cites W1185854923 @default.
• W4214915560 cites W1500648667 @default.
• W4214915560 cites W1617145133 @default.
• W4214915560 cites W1923289550 @default.
• W4214915560 cites W1943720579 @default.
• W4214915560 cites W1965964040 @default.
• W4214915560 cites W1981320739 @default.
• W4214915560 cites W1996431759 @default.
• W4214915560 cites W1996514604 @default.
• W4214915560 cites W2003313558 @default.
• W4214915560 cites W2014077667 @default.
• W4214915560 cites W2028689806 @default.
• W4214915560 cites W2032860037 @default.
• W4214915560 cites W2049300160 @default.
• W4214915560 cites W2050838276 @default.
• W4214915560 cites W2052013412 @default.
• W4214915560 cites W2052280647 @default.
• W4214915560 cites W2052657862 @default.
• W4214915560 cites W2060897834 @default.
• W4214915560 cites W2066563681 @default.
• W4214915560 cites W2075901208 @default.
• W4214915560 cites W2082276761 @default.
• W4214915560 cites W2083143922 @default.
• W4214915560 cites W2084748297 @default.
• W4214915560 cites W2087099947 @default.
• W4214915560 cites W2095237346 @default.
• W4214915560 cites W2112170577 @default.
• W4214915560 cites W2114970231 @default.
• W4214915560 cites W2124289914 @default.
• W4214915560 cites W2134150626 @default.
• W4214915560 cites W2136812326 @default.
• W4214915560 cites W2139122477 @default.
• W4214915560 cites W2144460023 @default.
• W4214915560 cites W2152435464 @default.
• W4214915560 cites W2161381087 @default.
• W4214915560 cites W2164575981 @default.
• W4214915560 cites W2172008925 @default.
• W4214915560 cites W2188288845 @default.
• W4214915560 cites W2238280291 @default.
• W4214915560 cites W2271674067 @default.
• W4214915560 cites W2277439059 @default.
• W4214915560 cites W2288780415 @default.
• W4214915560 cites W2295265201 @default.
• W4214915560 cites W2338439934 @default.
• W4214915560 cites W2340203805 @default.
• W4214915560 cites W2344750482 @default.
• W4214915560 cites W2401161026 @default.
• W4214915560 cites W2418655492 @default.
• W4214915560 cites W2532133902 @default.
• W4214915560 cites W2558947257 @default.
• W4214915560 cites W2587858407 @default.
• W4214915560 cites W2598895106 @default.
• W4214915560 cites W2606906244 @default.
• W4214915560 cites W2612643019 @default.
• W4214915560 cites W2751640021 @default.
• W4214915560 cites W2752652639 @default.
• W4214915560 cites W2757371372 @default.
• W4214915560 cites W2768766680 @default.
• W4214915560 cites W2775911402 @default.
• W4214915560 cites W2782409017 @default.
• W4214915560 cites W2804710032 @default.
• W4214915560 cites W2809000676 @default.
• W4214915560 cites W2847885306 @default.
• W4214915560 cites W2853495684 @default.
• W4214915560 cites W2893000701 @default.
• W4214915560 cites W2894991195 @default.
• W4214915560 cites W2896268692 @default.
• W4214915560 cites W2901398681 @default.
• W4214915560 cites W2904213144 @default.
• W4214915560 cites W2909240409 @default.
• W4214915560 cites W2911561283 @default.
• W4214915560 cites W2911802341 @default.
• W4214915560 cites W2949008664 @default.
• W4214915560 cites W2951550012 @default.
• W4214915560 cites W2952001149 @default.
• W4214915560 cites W2953545333 @default.
• W4214915560 cites W2956285279 @default.
• W4214915560 cites W2969382515 @default.
• W4214915560 cites W2971842001 @default.
• W4214915560 cites W2975520753 @default.
• W4214915560 cites W2977401128 @default.
• W4214915560 cites W2979343233 @default.
• W4214915560 cites W2981037708 @default.
• W4214915560 cites W2993308551 @default.
• W4214915560 cites W2993613795 @default.
• W4214915560 cites W2999031974 @default.
• W4214915560 cites W3008976461 @default.
• W4214915560 cites W3010892452 @default.

• next