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- W4214922102 abstract "Abstract Background: The IASLC lymph node map grouped the lymph node stations into zones for prognostic analyses. In the N1 lymph nodes group, N1 nodes are divided into the Hilar/Interlobar zone (N1h) and Peripheral zone (N1p). There is no consensus on the different prognostic values of N1 lymph nodes in N1h and N1p. Therefore, we conducted a systematic review and meta-analysis to assess the survival difference between N1h and N1p in patients of pN1M0 NSCLC. Methods: Medline, the Cochrane Library, Embase, and the Web of science were systematically searched to identify relevant studies published up to April 4th, 2020. A retrospective cohort study and prospective cohort study comparing N1h vs. N1p to the pN1M0 NSCLC were included. Hazard ratios (HRs) for OS were aggregated according to a fixed or random-effect model.Results: Ten publications for 1946 patients of pN1M0 NSCLC were included for the meta-analysis. OS was lower for patients with N1h (HR: 1.67, 95%CI 1.44-1.94; P < 0.001). The pooled 5-year OS in N1h and N1p were 40% and 56%, respectively.Conclusions: The patients in pN1M0 NSCLC have different survival according to different N1 lymph node zones involvement: patients with N1p metastasis have a better prognosis than those with N1h metastasis." @default.
- W4214922102 created "2022-03-05" @default.
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- W4214922102 date "2021-05-11" @default.
- W4214922102 modified "2023-09-27" @default.
- W4214922102 title "Prognostic Value of Different N1 Lymph Node Zones in pN1M0 Non-Small Cell Lung Cancer：A Systematic Review and Meta-Analysis." @default.
- W4214922102 doi "https://doi.org/10.21203/rs.3.rs-436886/v1" @default.
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