Matches in SemOpenAlex for { <https://semopenalex.org/work/W4214923044> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4214923044 abstract "Abstract Background: Tumor microenvironment (TME) plays a significant role in the development of cancer. However, the roles of TME in lung squamous cell carcinoma (LUSC) are not well studied. In our study, we aimed to identify differentially expressed tumor microenvironment-related genes as biomarker for predicting the prognosis of LUSC. Methods: We combined The Cancer Genome Atlas (TCGA) and Estimation of Stromal and Immune cells in Malignant Tumor tissue using Expression data (ESTIMATE) datasets to identified differentially expressed genes in lung squamous cell carcinoma microenvironment. Then, functional enrichment analysis and protein-protein interaction (PPI) network were conducted. The top six genes in the PPI network were regarded as tumor microenvironment-related hub genes. Finally, the relationship between hub genes and tumor-infiltrating immune cells was deciphered using TIMER. Results: Our study revealed that immune and stromal scores are associated with specific clinicopathologic variables in LUSC. These variables include gender, age, distant metastasis and prognosis. In addition, a total of 874 upregulated and 72 downregulated genes were identified. Functional enrichment analysis demonstrated a correlation between DEGs and the tumor microenvironment, tumor immune cells differentiation and activation. C3AR1, CSF1R, CCL2, CCR1, TYROBP, CD14were selected as the hub genes. A positive correlation was obtained between the expression of hub genes and the abundance of six immune cells. Conclusions: The results of the present study showed that ESTIMATE algorithm-based stromal and immune scores may be a reference indicator of cancer prognosis. We identified five TME-related genes, which could be used to predict the prognosis of LUSC patients." @default.
- W4214923044 created "2022-03-05" @default.
- W4214923044 creator A5010702785 @default.
- W4214923044 creator A5011645302 @default.
- W4214923044 creator A5020251798 @default.
- W4214923044 creator A5056310516 @default.
- W4214923044 creator A5075287925 @default.
- W4214923044 creator A5081675173 @default.
- W4214923044 date "2020-05-13" @default.
- W4214923044 modified "2023-09-23" @default.
- W4214923044 title "Mine TCGA Database for Tumor Microenvironment-Related Genes of Prognostic value in lung squamous cell carcinoma" @default.
- W4214923044 doi "https://doi.org/10.21203/rs.3.rs-28076/v1" @default.
- W4214923044 hasPublicationYear "2020" @default.
- W4214923044 type Work @default.
- W4214923044 citedByCount "0" @default.
- W4214923044 crossrefType "posted-content" @default.
- W4214923044 hasAuthorship W4214923044A5010702785 @default.
- W4214923044 hasAuthorship W4214923044A5011645302 @default.
- W4214923044 hasAuthorship W4214923044A5020251798 @default.
- W4214923044 hasAuthorship W4214923044A5056310516 @default.
- W4214923044 hasAuthorship W4214923044A5075287925 @default.
- W4214923044 hasAuthorship W4214923044A5081675173 @default.
- W4214923044 hasBestOaLocation W42149230441 @default.
- W4214923044 hasConcept C104317684 @default.
- W4214923044 hasConcept C121608353 @default.
- W4214923044 hasConcept C143998085 @default.
- W4214923044 hasConcept C16930146 @default.
- W4214923044 hasConcept C203014093 @default.
- W4214923044 hasConcept C2776107976 @default.
- W4214923044 hasConcept C2776256026 @default.
- W4214923044 hasConcept C2779013556 @default.
- W4214923044 hasConcept C502942594 @default.
- W4214923044 hasConcept C54355233 @default.
- W4214923044 hasConcept C71924100 @default.
- W4214923044 hasConcept C86803240 @default.
- W4214923044 hasConcept C8891405 @default.
- W4214923044 hasConceptScore W4214923044C104317684 @default.
- W4214923044 hasConceptScore W4214923044C121608353 @default.
- W4214923044 hasConceptScore W4214923044C143998085 @default.
- W4214923044 hasConceptScore W4214923044C16930146 @default.
- W4214923044 hasConceptScore W4214923044C203014093 @default.
- W4214923044 hasConceptScore W4214923044C2776107976 @default.
- W4214923044 hasConceptScore W4214923044C2776256026 @default.
- W4214923044 hasConceptScore W4214923044C2779013556 @default.
- W4214923044 hasConceptScore W4214923044C502942594 @default.
- W4214923044 hasConceptScore W4214923044C54355233 @default.
- W4214923044 hasConceptScore W4214923044C71924100 @default.
- W4214923044 hasConceptScore W4214923044C86803240 @default.
- W4214923044 hasConceptScore W4214923044C8891405 @default.
- W4214923044 hasLocation W42149230441 @default.
- W4214923044 hasOpenAccess W4214923044 @default.
- W4214923044 hasPrimaryLocation W42149230441 @default.
- W4214923044 hasRelatedWork W2033278321 @default.
- W4214923044 hasRelatedWork W2084400792 @default.
- W4214923044 hasRelatedWork W2551414968 @default.
- W4214923044 hasRelatedWork W2891095593 @default.
- W4214923044 hasRelatedWork W2953174154 @default.
- W4214923044 hasRelatedWork W3010976621 @default.
- W4214923044 hasRelatedWork W3015340136 @default.
- W4214923044 hasRelatedWork W3096600782 @default.
- W4214923044 hasRelatedWork W4213151053 @default.
- W4214923044 hasRelatedWork W4361823855 @default.
- W4214923044 isParatext "false" @default.
- W4214923044 isRetracted "false" @default.
- W4214923044 workType "article" @default.