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- W4214924886 abstract "The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and dendritic cells in response to microbial stimulation, has emerged as a critical promoter of chronic intestinal inflammation. Genome-wide association studies linking variants in IL23R to disease protection, bolstered by experimental evidence from colitis models, and the successful application of therapies against the IL-12/IL-23 shared p40 subunit in the treatment of inflammatory bowel disease [IBD] all provide compelling evidence of a crucial role for IL-23 in disease pathogenesis. Moreover, targeting the p19 subunit specific for IL-23 has shown considerable promise in recent phase 2 studies in IBD. The relative importance of the diverse immunological pathways downstream of IL-23 in propagating mucosal inflammation in the gut, however, remains contentious. Here we review current understanding of IL-23 biology and explore its pleiotropic effects on T cells, and innate lymphoid, myeloid and intestinal epithelial cells in the context of the pathogenesis of IBD. We furthermore discuss these pathways in the light of recent evidence from clinical trials and indicate emerging targets amenable to therapeutic intervention and translation into clinical practice." @default.
- W4214924886 created "2022-03-05" @default.
- W4214924886 creator A5050963621 @default.
- W4214924886 creator A5072012157 @default.
- W4214924886 date "2022-04-01" @default.
- W4214924886 modified "2023-10-18" @default.
- W4214924886 title "Interleukin-23 in the Pathogenesis of Inflammatory Bowel Disease and Implications for Therapeutic Intervention" @default.
- W4214924886 cites W1516263086 @default.
- W4214924886 cites W1523693806 @default.
- W4214924886 cites W1545517148 @default.
- W4214924886 cites W1569689791 @default.
- W4214924886 cites W1588732320 @default.
- W4214924886 cites W1608909099 @default.
- W4214924886 cites W1642457845 @default.
- W4214924886 cites W1670573097 @default.
- W4214924886 cites W1691245493 @default.
- W4214924886 cites W1806191714 @default.
- W4214924886 cites W1836263069 @default.
- W4214924886 cites W1847326477 @default.
- W4214924886 cites W1949309640 @default.
- W4214924886 cites W1963308907 @default.
- W4214924886 cites W1964300433 @default.
- W4214924886 cites W1965471441 @default.
- W4214924886 cites W1968138343 @default.
- W4214924886 cites W1969979508 @default.
- W4214924886 cites W1971119469 @default.
- W4214924886 cites W1973354423 @default.
- W4214924886 cites W1979011193 @default.
- W4214924886 cites W1980668544 @default.
- W4214924886 cites W1981197190 @default.
- W4214924886 cites W1981714996 @default.
- W4214924886 cites W1982496217 @default.
- W4214924886 cites W1982542795 @default.
- W4214924886 cites W1984873885 @default.
- W4214924886 cites W1993339415 @default.
- W4214924886 cites W1994107743 @default.
- W4214924886 cites W1995321760 @default.
- W4214924886 cites W1999195236 @default.
- W4214924886 cites W2002061924 @default.
- W4214924886 cites W2002159385 @default.
- W4214924886 cites W2006711580 @default.
- W4214924886 cites W2006835919 @default.
- W4214924886 cites W2010506461 @default.
- W4214924886 cites W2011197968 @default.
- W4214924886 cites W2011882192 @default.
- W4214924886 cites W2014750930 @default.
- W4214924886 cites W2017893786 @default.
- W4214924886 cites W2017987372 @default.
- W4214924886 cites W2019699182 @default.
- W4214924886 cites W2021740276 @default.
- W4214924886 cites W2022104546 @default.
- W4214924886 cites W2028057905 @default.
- W4214924886 cites W2029123674 @default.
- W4214924886 cites W2033289727 @default.
- W4214924886 cites W2046579578 @default.
- W4214924886 cites W2048030072 @default.
- W4214924886 cites W2057610674 @default.
- W4214924886 cites W2058520337 @default.
- W4214924886 cites W2058788372 @default.
- W4214924886 cites W2059364985 @default.
- W4214924886 cites W2061314812 @default.
- W4214924886 cites W2064500584 @default.
- W4214924886 cites W2064741210 @default.
- W4214924886 cites W2065031087 @default.
- W4214924886 cites W2065307318 @default.
- W4214924886 cites W2066609936 @default.
- W4214924886 cites W2068133245 @default.
- W4214924886 cites W2069375519 @default.
- W4214924886 cites W2069571875 @default.
- W4214924886 cites W2069931076 @default.
- W4214924886 cites W2070339416 @default.
- W4214924886 cites W2070715537 @default.
- W4214924886 cites W2072449713 @default.
- W4214924886 cites W2072723200 @default.
- W4214924886 cites W2076889715 @default.
- W4214924886 cites W2077531651 @default.
- W4214924886 cites W2078087255 @default.
- W4214924886 cites W2079267030 @default.
- W4214924886 cites W2082040247 @default.
- W4214924886 cites W2084388036 @default.
- W4214924886 cites W2085176939 @default.
- W4214924886 cites W2087727538 @default.
- W4214924886 cites W2087905758 @default.
- W4214924886 cites W2088449391 @default.
- W4214924886 cites W2092863985 @default.
- W4214924886 cites W2095690951 @default.
- W4214924886 cites W2096290681 @default.
- W4214924886 cites W2096853390 @default.
- W4214924886 cites W2097804771 @default.
- W4214924886 cites W2099662390 @default.
- W4214924886 cites W2100474263 @default.
- W4214924886 cites W2102865263 @default.
- W4214924886 cites W2103747137 @default.
- W4214924886 cites W2104201959 @default.
- W4214924886 cites W2104397453 @default.
- W4214924886 cites W2106779017 @default.
- W4214924886 cites W2107066107 @default.
- W4214924886 cites W2107235439 @default.