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- W4214938044 abstract "Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development of renal fibrosis. Recent advances suggest that SUMOylation functions as the promising intervening target against renal fibrosis, and natural products prevent renal fibrosis via modulating SUMOylation. Here, we introduce the mechanism of SUMOylation in renal fibrosis and therapeutic effects of natural products. This process starts by summarizing the key mediators and enzymes during SUMOylation and deSUMOylation and its regulation role in transcriptional factors and key mediators in renal fibrosis, then linking the mechanism findings of SUMOylation and natural products to develop novel therapeutic candidates for treating renal fibrosis, and concludes by commenting on promising therapeutic targets and candidate natural products in renal fibrosis via modulating SUMOylation, which highlights modulating SUMOylation as a promising strategy for natural products against renal fibrosis." @default.
- W4214938044 created "2022-03-05" @default.
- W4214938044 creator A5013038112 @default.
- W4214938044 creator A5018814025 @default.
- W4214938044 creator A5037015805 @default.
- W4214938044 creator A5059197874 @default.
- W4214938044 creator A5076247663 @default.
- W4214938044 creator A5088303852 @default.
- W4214938044 date "2022-03-04" @default.
- W4214938044 modified "2023-09-26" @default.
- W4214938044 title "Natural Products Against Renal Fibrosis via Modulation of SUMOylation" @default.
- W4214938044 cites W1603149409 @default.
- W4214938044 cites W1799534295 @default.
- W4214938044 cites W1973480232 @default.
- W4214938044 cites W1978783141 @default.
- W4214938044 cites W1979275431 @default.
- W4214938044 cites W1984222662 @default.
- W4214938044 cites W1992148723 @default.
- W4214938044 cites W1993180829 @default.
- W4214938044 cites W1996811697 @default.
- W4214938044 cites W2001367558 @default.
- W4214938044 cites W2002898689 @default.
- W4214938044 cites W2004722555 @default.
- W4214938044 cites W2020971467 @default.
- W4214938044 cites W2021246408 @default.
- W4214938044 cites W2030716084 @default.
- W4214938044 cites W2039490714 @default.
- W4214938044 cites W2046628354 @default.
- W4214938044 cites W2048370637 @default.
- W4214938044 cites W2054201731 @default.
- W4214938044 cites W2055376251 @default.
- W4214938044 cites W2064540966 @default.
- W4214938044 cites W2065605668 @default.
- W4214938044 cites W2073654240 @default.
- W4214938044 cites W2091010103 @default.
- W4214938044 cites W2102306514 @default.
- W4214938044 cites W2108247013 @default.
- W4214938044 cites W2108638545 @default.
- W4214938044 cites W2110886621 @default.
- W4214938044 cites W2115793088 @default.
- W4214938044 cites W2119653500 @default.
- W4214938044 cites W2121756243 @default.
- W4214938044 cites W2137772017 @default.
- W4214938044 cites W2145306271 @default.
- W4214938044 cites W2151801593 @default.
- W4214938044 cites W2152344589 @default.
- W4214938044 cites W2159406166 @default.
- W4214938044 cites W2163056216 @default.
- W4214938044 cites W2164467344 @default.
- W4214938044 cites W2285574364 @default.
- W4214938044 cites W2337814344 @default.
- W4214938044 cites W2402259557 @default.
- W4214938044 cites W2460450490 @default.
- W4214938044 cites W2592600610 @default.
- W4214938044 cites W2593998504 @default.
- W4214938044 cites W2752869742 @default.
- W4214938044 cites W2774981379 @default.
- W4214938044 cites W2778379027 @default.
- W4214938044 cites W2778430790 @default.
- W4214938044 cites W2783333988 @default.
- W4214938044 cites W2793014640 @default.
- W4214938044 cites W2901804928 @default.
- W4214938044 cites W2902825152 @default.
- W4214938044 cites W2913395593 @default.
- W4214938044 cites W2914077343 @default.
- W4214938044 cites W2914744518 @default.
- W4214938044 cites W2914939017 @default.
- W4214938044 cites W2942840247 @default.
- W4214938044 cites W2976176026 @default.
- W4214938044 cites W2980269837 @default.
- W4214938044 cites W2981284985 @default.
- W4214938044 cites W2987912279 @default.
- W4214938044 cites W2995653856 @default.
- W4214938044 cites W2995981370 @default.
- W4214938044 cites W3007757041 @default.
- W4214938044 cites W3008259925 @default.
- W4214938044 cites W3008588409 @default.
- W4214938044 cites W3012603098 @default.
- W4214938044 cites W3037604111 @default.
- W4214938044 cites W3041541923 @default.
- W4214938044 cites W3045049598 @default.
- W4214938044 cites W3047024853 @default.
- W4214938044 cites W3084673165 @default.
- W4214938044 cites W3120589563 @default.
- W4214938044 cites W3127491758 @default.
- W4214938044 cites W3128525092 @default.
- W4214938044 cites W3131069362 @default.
- W4214938044 cites W3133570207 @default.
- W4214938044 cites W3138247269 @default.
- W4214938044 cites W3157025738 @default.
- W4214938044 cites W3157656501 @default.
- W4214938044 cites W3161815541 @default.
- W4214938044 cites W3178086729 @default.
- W4214938044 cites W3183609797 @default.
- W4214938044 cites W3184297212 @default.
- W4214938044 cites W3185324405 @default.
- W4214938044 cites W3186047097 @default.
- W4214938044 cites W3189213208 @default.
- W4214938044 cites W3191763922 @default.
- W4214938044 cites W3193584608 @default.