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- W4220652378 endingPage "1428" @default.
- W4220652378 startingPage "1428" @default.
- W4220652378 abstract "Therapeutic advancements in neuroendocrine tumors (NETs) have improved survival outcomes. This study aims to review the impact of the current therapeutics on health-related quality of life (HRQoL) in NET patients. A literature review was performed utilizing PubMed, The Cochrane Library, and EMBASE, using the keywords Carcinoid, Neuroendocrine tumor, NET, Quality of life, Chemotherapy, Chemoembolization, Radiofrequency ablation, Peptide receptor radionucleotide therapy, PRRT, Surgery, Everolimus, Octreotide, Lanreotide, Sunitinib, and Somatostatin analog. Letters, editorials, narrative reviews, case reports, and studies not in English were excluded. Out of 2375 publications, 61 studies met our inclusion criteria. The commonly used instruments were EORTC QLQ-C30, FACT G, and EORTC- QLQ GI.NET-21. HRQoL was assessed in all pivotal trials that led to approvals of systemic therapies. All systemic therapies showed no worsening in HRQoL. The NETTER-1 study was the only study to show a statistically significant improvement in HRQoL in several domains. The trial examining sunitinib versus placebo in pancreatic NETs showed no change in QoL, except for worsening of diarrhea. In addition to clinical outcomes, patient-reported outcomes are a key element in making appropriate treatment decisions. HRQoL data should be readily provided to patients to assist in shared decision-making." @default.
- W4220652378 created "2022-04-03" @default.
- W4220652378 creator A5015969652 @default.
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- W4220652378 creator A5055725897 @default.
- W4220652378 creator A5068503288 @default.
- W4220652378 creator A5079117128 @default.
- W4220652378 date "2022-03-10" @default.
- W4220652378 modified "2023-10-15" @default.
- W4220652378 title "Health-Related Quality of Life (HRQoL) in Neuroendocrine Tumors: A Systematic Review" @default.
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- W4220652378 doi "https://doi.org/10.3390/cancers14061428" @default.
- W4220652378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35326587" @default.