Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220654450> ?p ?o ?g. }
- W4220654450 abstract "Microglia are the resident immune cells of the central nervous system (CNS) and play a key role in maintaining the normal function of the retina and brain. During early development, microglia migrate into the retina, transform into a highly ramified phenotype, and scan their environment constantly. Microglia can be activated by any homeostatic disturbance that may endanger neurons and threaten tissue integrity. Once activated, the young microglia exhibit a high diversity in their phenotypes as well as their functions, which relate to either beneficial or harmful consequences. Microglial activation is associated with the release of cytokines, chemokines, and growth factors that can determine pathological outcomes. As the professional phagocytes in the retina, microglia are responsible for the clearance of pathogens, dead cells, and protein aggregates. However, their phenotypic diversity and phagocytic capacity is compromised with ageing. This may result in the accumulation of protein aggregates and myelin debris leading to retinal neuroinflammation and neurodegeneration. In this review, we describe microglial phenotypes and functions in the context of the young and ageing retina, and the mechanisms underlying changes in ageing. Additionally, we review microglia-mediated retinal neuroinflammation and discuss the mechanisms of microglial involvement in retinal neurodegenerative diseases." @default.
- W4220654450 created "2022-04-03" @default.
- W4220654450 creator A5007827343 @default.
- W4220654450 creator A5030736220 @default.
- W4220654450 creator A5044451478 @default.
- W4220654450 creator A5091189457 @default.
- W4220654450 date "2022-03-17" @default.
- W4220654450 modified "2023-10-18" @default.
- W4220654450 title "Microglia: Key Players in Retinal Ageing and Neurodegeneration" @default.
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