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- W4220654839 abstract "In vitro and in vivo results showed that solamargine (SM) significantly inhibited the growth and enhanced the antitumor effect of sorafenib by regulating the HOTTIP-TUG1/miR-4726-5p/MUC1 signaling pathway in hepatocellular carcinoma (HCC). In brief, SM significantly downregulated the expression of long noncoding RNA HOTTIP and TUG1. Overexpression of HOTTIP and TUG1 decreased miR-4726-5p and reversed the effect of SM-increased expression of miR-4726-5p through acting the sponges of miR-4726-5p. Moreover, miR-4726-5p directly bound to the 3′-UTR region of MUC1, followed by reducing the expression of MUC1 protein. On the other hand, SM drastically decreased the promoter activity and protein expression of MUC1, overexpression of MUC1 significantly reversed the inhibitory effect of SM on HCC cells. More importantly, the combination of SM and sorafenib have a remarkable synergy on the downregulation of MUC1 and growth inhibition of HCC. Therefore, MUC1 may be the criticaltarget in the SM-induced growth inhibition and the anticancer synergy effect of SM and sorafenib in HCC." @default.
- W4220654839 created "2022-04-03" @default.
- W4220654839 date "2022-04-01" @default.
- W4220654839 modified "2023-10-17" @default.
- W4220654839 doi "https://doi.org/10.1002/mc.v61.4" @default.
- W4220654839 hasPublicationYear "2022" @default.
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