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- W4220654911 abstract "We have developed a triple pH/redox/ultrasound-triggered hybrid nanocarrier system for controlled drug delivery. This multifunctional hybrid system was synthesized as a core/shell nanoparticle consisting of mesoporous silica coated magnetic core (Fe3O4@SiO2@mSiO2) and pH/redox-responsive polymer layer. We synthesized lipoic acid (LA)-conjugated chitosan (CS) polymer as pH/redox-responsive polymer (CS-LA) layer of the particles. Then the synthesized ellipsoidal Fe3O4@SiO2@mSiO2 nanoparticles were coated by CS-LA polymer. To prepare triple-responsive release system, the LA components of the CS-LA polymer layer were crosslinked by DTT. The results showed that the hybrid nanoparticles exhibited an efficient DOX release in cellular pH environment. In addition, the dual pH/redox-responsive drug release results exhibited that the hybrid nanoparticles showed an efficient and controlled drug release profile in the presence of 10 mM GSH at pH = 5.5 at 37 °C within 24 h. Ultrasound (US)-induced release profile of the hybrid nanoparticles showed that the DOX release behaviour was controlled effectively by US-triggered. In vitro cytotoxicity tests exhibited that DOX loaded hybrid nanoparticles provide an efficient cell death in MCF-7 cells at pH = 5.5. In our belief, these triple-triggered hybrid nanoparticles have promising potential for controlled drug release and are worth doing further in vivo research." @default.
- W4220654911 created "2022-04-03" @default.
- W4220654911 creator A5010658556 @default.
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- W4220654911 date "2022-05-01" @default.
- W4220654911 modified "2023-09-29" @default.
- W4220654911 title "Ultrasound/redox/pH-responsive hybrid nanoparticles for triple-triggered drug delivery" @default.
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- W4220654911 doi "https://doi.org/10.1016/j.jddst.2022.103267" @default.
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