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• W4220655266 abstract "Developing artificial metalloenzymes that possess a superior performance to their natural counterparts is an attractive concept. Polyoxometalates (POMs) are a class of anionic molecular metal-oxides with excellent redox properties and bioactivity. We have recently introduced POMlymers - covalently conjugated POM-peptide hybrid materials - where the polypeptide chain is obtained through a ring-opening polymerisation (ROP) of α-amino acid N-carboxyanhydrides (NCA) on an inorganic POM scaffold. Attracted by the idea of preparing artificial metalloenzymes, here we report the supramolecular self-assembly of POMlymer hybrids into nanoparticles where an optimal environment for catalysis is created. Our results demonstrate that the self-assembly of covalent POMlymers, enhances the peroxidase-like activity of the parent POM anion whereas, in contrast, the catalytic activity for nanoparticles obtained by ionic self-assembly of the same peptide and POM components practically disappears. Furthermore, POMlymer nanoparticles also present antimicrobial and antibiofilm activity against the skin bacterium Staphylococcus epidermidis; whereas, ionic POM-peptide hybrids significantly increase biofilm production and endogenous production of reactive oxygen species. In summary, we present the self-assembly of POMlymer hybrids into nanoparticles and a combination of peroxidase activity and microbiology assays that show that the POM-peptide covalent bond is essential for the stability of the self-assembled nanoparticles and therefore for their catalytic and biological activity." @default.
• W4220655266 created "2022-04-03" @default.
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• W4220655266 date "2022-01-01" @default.
• W4220655266 modified "2023-10-14" @default.
• W4220655266 title "Polyoxometalate–polypeptide nanoassemblies as peroxidase surrogates with antibiofilm properties" @default.
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• W4220655266 doi "https://doi.org/10.1039/d1nr08223j" @default.
• W4220655266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35348148" @default.
• W4220655266 hasPublicationYear "2022" @default.
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