Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220656480> ?p ?o ?g. }
- W4220656480 abstract "Abstract Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident memory T-cells (T RM ). Here, we show that higher intratumoural frequencies of γδ T-cells, which have potential for HLA-unrestricted tumour reactivity, associate with enhanced HCC patient survival. We demonstrate that γδ T-cells exhibit bona fide tissue-residency in human liver and HCC, with γδT RM showing no egress from hepatic vasculature, persistence for >10 years and superior anti-tumour cytokine production. The Vγ9Vδ2 T-cell subset is selectively depleted in HCC but can efficiently target HCC cell lines sensitised to accumulate isopentenyl-pyrophosphate by the aminobisphosphonate Zoledronic acid. Aminobisphosphonate-based expansion of peripheral Vγ9Vδ2 T-cells recapitulates a T RM phenotype and boosts cytotoxic potential. Thus, our data suggest more universally effective HCC immunotherapy may be achieved by combining aminobisphosphonates to induce Vγ9Vδ2T RM capable of replenishing the depleted pool, with additional intratumoural delivery to sensitise HCC to Vγ9Vδ2T RM -based targeting." @default.
- W4220656480 created "2022-04-03" @default.
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- W4220656480 date "2022-03-16" @default.
- W4220656480 modified "2023-10-05" @default.
- W4220656480 title "Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma" @default.
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- W4220656480 doi "https://doi.org/10.1038/s41467-022-29012-1" @default.
- W4220656480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35296658" @default.
- W4220656480 hasPublicationYear "2022" @default.
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