Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220656852> ?p ?o ?g. }
- W4220656852 endingPage "111616" @default.
- W4220656852 startingPage "111616" @default.
- W4220656852 abstract "Farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates bile acid homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR expression has been widely noted in kidney, adrenal gland, pancreas, adipose, skeletal muscle, heart, and brain. Except for the liver and gut, the relevance of FXR signaling in metabolism in other tissues remains poorly understood. This review examines the classical and non-canonical tissue-specific roles of FXR in regulating, lipids, and glucose homeostasis under normal and diseased states. FXR activation has been reported to be protective against cholestasis, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), type 2 diabetes, cardiovascular and kidney diseases. Several ongoing clinical trials are investigating FXR ligands as a therapeutic target for primary biliary cholangitis (PBC) and NASH, which substantiate the significance of FXR signaling in modulating metabolic processes. This review highlights that FXR ligands, albeit an attractive therapeutic target for treating metabolic diseases, tissue-specific modulation of FXR may be the key to overcoming some of the adverse clinical effects." @default.
- W4220656852 created "2022-04-03" @default.
- W4220656852 creator A5060958733 @default.
- W4220656852 creator A5074013601 @default.
- W4220656852 date "2022-06-01" @default.
- W4220656852 modified "2023-10-18" @default.
- W4220656852 title "Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism" @default.
- W4220656852 cites W1677336966 @default.
- W4220656852 cites W1821582942 @default.
- W4220656852 cites W1963587340 @default.
- W4220656852 cites W1964777932 @default.
- W4220656852 cites W1964823824 @default.
- W4220656852 cites W1966052494 @default.
- W4220656852 cites W1966922165 @default.
- W4220656852 cites W1970363592 @default.
- W4220656852 cites W1975673963 @default.
- W4220656852 cites W1976621716 @default.
- W4220656852 cites W1978393281 @default.
- W4220656852 cites W1982237658 @default.
- W4220656852 cites W1986093357 @default.
- W4220656852 cites W1988012657 @default.
- W4220656852 cites W1989357395 @default.
- W4220656852 cites W1990819179 @default.
- W4220656852 cites W1991315671 @default.
- W4220656852 cites W1995076942 @default.
- W4220656852 cites W1995378042 @default.
- W4220656852 cites W1999013381 @default.
- W4220656852 cites W2003008866 @default.
- W4220656852 cites W2003877378 @default.
- W4220656852 cites W2003905949 @default.
- W4220656852 cites W2005456200 @default.
- W4220656852 cites W2008165628 @default.
- W4220656852 cites W2010267799 @default.
- W4220656852 cites W2018589206 @default.
- W4220656852 cites W2020515276 @default.
- W4220656852 cites W2022186415 @default.
- W4220656852 cites W2024685706 @default.
- W4220656852 cites W2025138661 @default.
- W4220656852 cites W2029730391 @default.
- W4220656852 cites W2039387079 @default.
- W4220656852 cites W2039768005 @default.
- W4220656852 cites W2040086341 @default.
- W4220656852 cites W2041451676 @default.
- W4220656852 cites W2044686871 @default.
- W4220656852 cites W2045223517 @default.
- W4220656852 cites W2046811888 @default.
- W4220656852 cites W2051040521 @default.
- W4220656852 cites W2051570780 @default.
- W4220656852 cites W2052062339 @default.
- W4220656852 cites W2052991255 @default.
- W4220656852 cites W2053302563 @default.
- W4220656852 cites W2053581007 @default.
- W4220656852 cites W2054339027 @default.
- W4220656852 cites W2054462517 @default.
- W4220656852 cites W2055543010 @default.
- W4220656852 cites W2056737340 @default.
- W4220656852 cites W2060115626 @default.
- W4220656852 cites W2060252228 @default.
- W4220656852 cites W2063502039 @default.
- W4220656852 cites W2064602736 @default.
- W4220656852 cites W2064662214 @default.
- W4220656852 cites W2065051999 @default.
- W4220656852 cites W2065147071 @default.
- W4220656852 cites W2069385298 @default.
- W4220656852 cites W2070428103 @default.
- W4220656852 cites W2075017111 @default.
- W4220656852 cites W2084307588 @default.
- W4220656852 cites W2086993550 @default.
- W4220656852 cites W2087779371 @default.
- W4220656852 cites W2093457972 @default.
- W4220656852 cites W2093680171 @default.
- W4220656852 cites W2095919437 @default.
- W4220656852 cites W2097631494 @default.
- W4220656852 cites W2103218950 @default.
- W4220656852 cites W2105866876 @default.
- W4220656852 cites W2106678312 @default.
- W4220656852 cites W2106768039 @default.
- W4220656852 cites W2106986971 @default.
- W4220656852 cites W2107009647 @default.
- W4220656852 cites W2107051699 @default.
- W4220656852 cites W2108641213 @default.
- W4220656852 cites W2109127510 @default.
- W4220656852 cites W2112644387 @default.
- W4220656852 cites W2115438056 @default.
- W4220656852 cites W2119560584 @default.
- W4220656852 cites W2122478167 @default.
- W4220656852 cites W2122709204 @default.
- W4220656852 cites W2122860085 @default.
- W4220656852 cites W2123561714 @default.
- W4220656852 cites W2124025733 @default.
- W4220656852 cites W2125457175 @default.
- W4220656852 cites W2125629031 @default.
- W4220656852 cites W2128742947 @default.
- W4220656852 cites W2130289287 @default.
- W4220656852 cites W2131655174 @default.
- W4220656852 cites W2131873070 @default.
- W4220656852 cites W2132302780 @default.
- W4220656852 cites W2142427646 @default.