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- W4220656927 abstract "Virus-like particle (VLPs) vaccines have been extensively studied due to their good immunogenicity and safety; however, they highly rely on cold-chain storage and transportation. Nanotechnology of bio-mineralization as a useful strategy has been employed to improve the thermal stability and immunogenicity of VLPs. A zeolitic imidazole framework (ZIF-8), a core-shell structured nanocomposite, was applied to encapsulate foot-and-mouth disease virus (FMDV) VLPs. It was found that the ZIF-8 shell enhanced the heat resistance of VLPs and promoted their ability to be taken up by cells and escape from lysosomes. The VLPs-ZIF-8 easily activated antigen-presenting cells (APCs), triggered higher secretion levels of cytokines, and elicited stronger immune responses than VLPs alone even after being treated at 37 °C for 7 days. This platform has good potential in the development of VLP-based vaccine products without transportation." @default.
- W4220656927 created "2022-04-03" @default.
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- W4220656927 date "2022-01-01" @default.
- W4220656927 modified "2023-10-14" @default.
- W4220656927 title "Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines" @default.
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- W4220656927 doi "https://doi.org/10.1039/d1tb02719k" @default.
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