FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220657070> ?p ?o ?g. }

• W4220657070 abstract "The prognostic value of ground glass opacity (GGO) in stage IA non-small cell lung cancer (NSCLC) has been widely recognized. However, studies investigating its value in the related stage IB-IIA lung adenocarcinoma (LUAD) remains lacking. The impact of adjuvant chemotherapy (ACT) on pathological stage IB-IIA LUAD is also controversial.We retrospectively reviewed the clinical records of 501 patients with pathological stage IB-IIA LUAD at the Sun Yat-sen University Cancer Center from January 2008 to June 2018. We calculated and compared survival curves using the Kaplan-Meier test and log-rank test. Cox regression models were performed to determine independent prognostic factors of disease-free survival (DFS) and overall survival (OS). We established nomograms to predict the OS and DFS of LUAD patients. Calibration and receiver operator characteristic curves were conducted to assess the predictive performance of two nomograms. Based on the nomogram, we identified candidate patients that may most benefit from ACT after surgery.The number of patients with pure solid, part GGO, and pure GGO nodules was 240, 242, and 19, respectively, and 125 patients who received ACT. Patients with consolidation-to-tumor ratio (CTR) <0.75 had longer OS (P = 0.026) and DFS (P = 0.003). Pathological tumor size and at least 10 lymph nodes (LNs) resection were independent prognostic factors of both OS and DFS. CTR <0.75 was positively associated with DFS. The C-index of nomograms predicting individual OS and DFS was 0.660 and 0.634, respectively. Based on the nomogram for OS, ACT was found to be a positive prognostic indicator of OS (P = 0.031, HR = 0.5141, 95% CI 0.281-0.942) in patients with nomogram total points ≥5.CTR <0.75 is associated with a better DFS in patients with stage IB-IIA LUAD. Nomograms developed by integrating pathological tumor size, at least 10 LNs resection, and CTR ≥0.75 for predicting individual OS and DFS displayed a good predictive capacity and clinical value, which were also proved to be a useful tool for selecting patients most benefiting from ACT." @default.
• W4220657070 created "2022-04-03" @default.
• W4220657070 creator A5005879655 @default.
• W4220657070 creator A5009420717 @default.
• W4220657070 creator A5015583741 @default.
• W4220657070 creator A5019072602 @default.
• W4220657070 creator A5024090925 @default.
• W4220657070 creator A5051350748 @default.
• W4220657070 creator A5075546285 @default.
• W4220657070 creator A5088359700 @default.
• W4220657070 creator A5089512092 @default.
• W4220657070 date "2022-03-25" @default.
• W4220657070 modified "2023-10-14" @default.
• W4220657070 title "Ground Glass Opacity and Adjuvant Chemotherapy in Pathological Stage IB–IIA Lung Adenocarcinoma" @default.
• W4220657070 cites W1975727847 @default.
• W4220657070 cites W2068762252 @default.
• W4220657070 cites W2073768470 @default.
• W4220657070 cites W2114855342 @default.
• W4220657070 cites W2117994949 @default.
• W4220657070 cites W2127342594 @default.
• W4220657070 cites W2132314250 @default.
• W4220657070 cites W2158234609 @default.
• W4220657070 cites W2228221433 @default.
• W4220657070 cites W2507737385 @default.
• W4220657070 cites W2521657898 @default.
• W4220657070 cites W2530388046 @default.
• W4220657070 cites W2562479190 @default.
• W4220657070 cites W2594914340 @default.
• W4220657070 cites W2607148107 @default.
• W4220657070 cites W2611303424 @default.
• W4220657070 cites W2753797290 @default.
• W4220657070 cites W2767598117 @default.
• W4220657070 cites W2884953777 @default.
• W4220657070 cites W2921803619 @default.
• W4220657070 cites W2941100792 @default.
• W4220657070 cites W2969900393 @default.
• W4220657070 cites W3086390425 @default.
• W4220657070 cites W3095430596 @default.
• W4220657070 cites W3107853755 @default.
• W4220657070 cites W3112900229 @default.
• W4220657070 cites W3113208909 @default.
• W4220657070 cites W3128646645 @default.
• W4220657070 cites W3155219891 @default.
• W4220657070 cites W3204428447 @default.
• W4220657070 doi "https://doi.org/10.3389/fonc.2022.851276" @default.
• W4220657070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35402251" @default.
• W4220657070 hasPublicationYear "2022" @default.
• W4220657070 type Work @default.
• W4220657070 citedByCount "2" @default.
• W4220657070 countsByYear W42206570702022 @default.
• W4220657070 countsByYear W42206570702023 @default.
• W4220657070 crossrefType "journal-article" @default.
• W4220657070 hasAuthorship W4220657070A5005879655 @default.
• W4220657070 hasAuthorship W4220657070A5009420717 @default.
• W4220657070 hasAuthorship W4220657070A5015583741 @default.
• W4220657070 hasAuthorship W4220657070A5019072602 @default.
• W4220657070 hasAuthorship W4220657070A5024090925 @default.
• W4220657070 hasAuthorship W4220657070A5051350748 @default.
• W4220657070 hasAuthorship W4220657070A5075546285 @default.
• W4220657070 hasAuthorship W4220657070A5088359700 @default.
• W4220657070 hasAuthorship W4220657070A5089512092 @default.
• W4220657070 hasBestOaLocation W42206570701 @default.
• W4220657070 hasConcept C121608353 @default.
• W4220657070 hasConcept C126322002 @default.
• W4220657070 hasConcept C126838900 @default.
• W4220657070 hasConcept C141071460 @default.
• W4220657070 hasConcept C143998085 @default.
• W4220657070 hasConcept C146357865 @default.
• W4220657070 hasConcept C151730666 @default.
• W4220657070 hasConcept C159110652 @default.
• W4220657070 hasConcept C207886595 @default.
• W4220657070 hasConcept C2776256026 @default.
• W4220657070 hasConcept C2777001051 @default.
• W4220657070 hasConcept C2778132481 @default.
• W4220657070 hasConcept C2780091936 @default.
• W4220657070 hasConcept C2780849966 @default.
• W4220657070 hasConcept C2781182431 @default.
• W4220657070 hasConcept C34626388 @default.
• W4220657070 hasConcept C50382708 @default.
• W4220657070 hasConcept C71924100 @default.
• W4220657070 hasConcept C86803240 @default.
• W4220657070 hasConceptScore W4220657070C121608353 @default.
• W4220657070 hasConceptScore W4220657070C126322002 @default.
• W4220657070 hasConceptScore W4220657070C126838900 @default.
• W4220657070 hasConceptScore W4220657070C141071460 @default.
• W4220657070 hasConceptScore W4220657070C143998085 @default.
• W4220657070 hasConceptScore W4220657070C146357865 @default.
• W4220657070 hasConceptScore W4220657070C151730666 @default.
• W4220657070 hasConceptScore W4220657070C159110652 @default.
• W4220657070 hasConceptScore W4220657070C207886595 @default.
• W4220657070 hasConceptScore W4220657070C2776256026 @default.
• W4220657070 hasConceptScore W4220657070C2777001051 @default.
• W4220657070 hasConceptScore W4220657070C2778132481 @default.
• W4220657070 hasConceptScore W4220657070C2780091936 @default.
• W4220657070 hasConceptScore W4220657070C2780849966 @default.
• W4220657070 hasConceptScore W4220657070C2781182431 @default.
• W4220657070 hasConceptScore W4220657070C34626388 @default.
• W4220657070 hasConceptScore W4220657070C50382708 @default.
• W4220657070 hasConceptScore W4220657070C71924100 @default.
• W4220657070 hasConceptScore W4220657070C86803240 @default.

• next