FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220658629> ?p ?o ?g. }

• W4220658629 endingPage "3109" @default.
• W4220658629 startingPage "3091" @default.
• W4220658629 abstract "We aim to investigate the mechanisms underlying the beneficial effects of exercise rehabilitation (ER) and/or astragaloside (AST) in counteracting amyloid-beta (Aβ) pathology. Aβ oligomers were microinjected into the bilateral ventricles to induce Aβ neuropathology in rats. Neurobehavioral functions were evaluated. Cortical and hippocampal expressions of both BDNF/TrkB and cathepsin D were determined by the western blotting method. The rat primary cultured cortical neurons were incubated with BDNF and/or AST and ANA12 followed by exposure to aggregated Aβ for 24 h. In vivo results showed that ER and/or AST reversed neurobehavioral disorders, downregulation of cortical and hippocampal expression of both BDNF/TrkB and cathepsin D, neural pathology, Aβ accumulation, and altered microglial polarization caused by Aβ. In vitro studies also confirmed that topical application of BDNF and/or AST reversed the Aβ-induced cytotoxicity, apoptosis, mitochondrial distress, and synaptotoxicity and decreased expression of p-TrkB, p-Akt, p-GSK3β, and β-catenin in rat cortical neurons. The beneficial effects of combined ER (or BDNF) and AST therapy in vivo and in vitro were superior to ER (or BDNF) or AST alone. Furthermore, we observed that any gains from ER (or BDNF) and/or AST could be significantly eliminated by ANA-12, a potent BDNF/TrkB antagonist. These results indicate that whereas ER (or BDNF) and/or AST attenuate Aβ pathology by reversing BDNF/TrkB signaling deficits and mitochondrial dysfunction, combining these two potentiates each other's therapeutic effects. In particular, AST can be an alternative therapy to replace ER." @default.
• W4220658629 created "2022-04-03" @default.
• W4220658629 creator A5009265860 @default.
• W4220658629 creator A5025329742 @default.
• W4220658629 creator A5027364609 @default.
• W4220658629 creator A5027507139 @default.
• W4220658629 creator A5032571858 @default.
• W4220658629 creator A5040304138 @default.
• W4220658629 creator A5062046621 @default.
• W4220658629 creator A5063190209 @default.
• W4220658629 creator A5079646688 @default.
• W4220658629 date "2022-03-09" @default.
• W4220658629 modified "2023-10-15" @default.
• W4220658629 title "Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction" @default.
• W4220658629 cites W1685999671 @default.
• W4220658629 cites W1817467313 @default.
• W4220658629 cites W1968973248 @default.
• W4220658629 cites W1969458773 @default.
• W4220658629 cites W1978714931 @default.
• W4220658629 cites W1979702721 @default.
• W4220658629 cites W1992826764 @default.
• W4220658629 cites W1995527759 @default.
• W4220658629 cites W2004665203 @default.
• W4220658629 cites W2013933160 @default.
• W4220658629 cites W2014526361 @default.
• W4220658629 cites W2022545956 @default.
• W4220658629 cites W2026845929 @default.
• W4220658629 cites W2030069255 @default.
• W4220658629 cites W2035521611 @default.
• W4220658629 cites W2037923368 @default.
• W4220658629 cites W2041285433 @default.
• W4220658629 cites W2049069390 @default.
• W4220658629 cites W2050506828 @default.
• W4220658629 cites W2051629576 @default.
• W4220658629 cites W2057306734 @default.
• W4220658629 cites W2066110504 @default.
• W4220658629 cites W2074948025 @default.
• W4220658629 cites W2077701948 @default.
• W4220658629 cites W2089058043 @default.
• W4220658629 cites W2092588620 @default.
• W4220658629 cites W2094958540 @default.
• W4220658629 cites W2125977732 @default.
• W4220658629 cites W2147180300 @default.
• W4220658629 cites W2151986987 @default.
• W4220658629 cites W2165419400 @default.
• W4220658629 cites W2168345701 @default.
• W4220658629 cites W2176039087 @default.
• W4220658629 cites W2203228701 @default.
• W4220658629 cites W2289518141 @default.
• W4220658629 cites W2532689563 @default.
• W4220658629 cites W2538131043 @default.
• W4220658629 cites W2599676172 @default.
• W4220658629 cites W2600687924 @default.
• W4220658629 cites W2610098090 @default.
• W4220658629 cites W2797459878 @default.
• W4220658629 cites W2891373107 @default.
• W4220658629 cites W2944325272 @default.
• W4220658629 cites W2947175258 @default.
• W4220658629 cites W2967342569 @default.
• W4220658629 cites W2972643865 @default.
• W4220658629 cites W2999362366 @default.
• W4220658629 cites W3038492333 @default.
• W4220658629 cites W3134183645 @default.
• W4220658629 cites W3185238913 @default.
• W4220658629 cites W4296816736 @default.
• W4220658629 doi "https://doi.org/10.1007/s12035-022-02728-3" @default.
• W4220658629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35262870" @default.
• W4220658629 hasPublicationYear "2022" @default.
• W4220658629 type Work @default.
• W4220658629 citedByCount "6" @default.
• W4220658629 countsByYear W42206586292022 @default.
• W4220658629 countsByYear W42206586292023 @default.
• W4220658629 crossrefType "journal-article" @default.
• W4220658629 hasAuthorship W4220658629A5009265860 @default.
• W4220658629 hasAuthorship W4220658629A5025329742 @default.
• W4220658629 hasAuthorship W4220658629A5027364609 @default.
• W4220658629 hasAuthorship W4220658629A5027507139 @default.
• W4220658629 hasAuthorship W4220658629A5032571858 @default.
• W4220658629 hasAuthorship W4220658629A5040304138 @default.
• W4220658629 hasAuthorship W4220658629A5062046621 @default.
• W4220658629 hasAuthorship W4220658629A5063190209 @default.
• W4220658629 hasAuthorship W4220658629A5079646688 @default.
• W4220658629 hasBestOaLocation W42206586292 @default.
• W4220658629 hasConcept C126322002 @default.
• W4220658629 hasConcept C134018914 @default.
• W4220658629 hasConcept C160539049 @default.
• W4220658629 hasConcept C170493617 @default.
• W4220658629 hasConcept C185592680 @default.
• W4220658629 hasConcept C25498285 @default.
• W4220658629 hasConcept C2776156579 @default.
• W4220658629 hasConcept C2778790584 @default.
• W4220658629 hasConcept C2779134260 @default.
• W4220658629 hasConcept C71924100 @default.
• W4220658629 hasConcept C97124661 @default.
• W4220658629 hasConcept C98274493 @default.
• W4220658629 hasConceptScore W4220658629C126322002 @default.
• W4220658629 hasConceptScore W4220658629C134018914 @default.
• W4220658629 hasConceptScore W4220658629C160539049 @default.

• next