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- W4220659493 abstract "Abstract Mechanical constraints have a high impact on development processes, and there is a need for new tools to investigate the role of mechanosensitive pathways in tissue reorganization during development. We present here experiments where embryonic cell aggregates are aspired through constrictions in microfluidic channels, generating highly heterogeneous flows and high cell deformations that can be imaged using two-photon microscopy. This approach provides a way to measure in situ local viscoelastic properties of 3D tissues and connect them to intracellular and intercellular events such as cell shape changes and cell rearrangements. Perspectives include applications on organoids to investigate and quantify rheological properties of tissues, and to understand how constraints affect development." @default.
- W4220659493 created "2022-04-03" @default.
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- W4220659493 date "2022-03-17" @default.
- W4220659493 modified "2023-10-15" @default.
- W4220659493 title "A microfluidic platform to investigate the role of mechanical constraints on tissue reorganization" @default.
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- W4220659493 doi "https://doi.org/10.1101/2022.03.16.484527" @default.
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