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• W4220659852 abstract "Abstract In neuroscience research, the refined analysis of rodent locomotion is complex and cumbersome, and access to the technique is limited because of the necessity for expensive equipment. In this study, we implemented a new deep learning-based open-source toolbox for Automated Limb Motion Analysis (ALMA) that requires only basic behavioral equipment and an inexpensive camera. The ALMA toolbox enables the consistent and comprehensive analyses of locomotor kinematics and paw placement and can be applied to neurological conditions affecting the brain and spinal cord. We demonstrated that the ALMA toolbox can (1) robustly track the evolution of locomotor deficits after spinal cord injury, (2) sensitively detect locomotor abnormalities after traumatic brain injury, and (3) correctly predict disease onset in a multiple sclerosis model. We, therefore, established a broadly applicable automated and standardized approach that requires minimal financial and time commitments to facilitate the comprehensive analysis of locomotion in rodent disease models." @default.
• W4220659852 created "2022-04-03" @default.
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• W4220659852 date "2022-02-15" @default.
• W4220659852 modified "2023-10-15" @default.
• W4220659852 title "A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders" @default.
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• W4220659852 doi "https://doi.org/10.1038/s42003-022-03077-6" @default.
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