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- W4220661857 abstract "Chronic obstructive pulmonary disease (COPD) is one of the major diseases threatening human life and health. According to the report released by the World Health Organization (WHO) in 2020, COPD has become the third leading cause of death in the world, featuring a sustainable growth of incidence rate as well as population age. The purpose of this review focuses on the advancement of bioactive natural compounds, such as baicalin, quercetin, resveratrol, and curcumin, which demonstrate promising therapeutic/interventional effects on CODP in vitro and in vivo. Information emphasizing on COPD was systematically collected from several authoritative internet databases including Web of Science, PubMed, Elsevier, Wiley Online Library, and Europe PMC, with a combination of keywords containing COPD and natural small molecular compounds. The new evidence indicated that these valuable molecules featured unique functions in the treatment of COPD through various biological processes such as anti-inflammatory, anti-oxidant, anti-apoptosis, and anti-airway fibrosis. Moreover, we found that the promising effects of these natural compounds on COPD were mainly achieved through JAK3/STAT3/NF-κB and MAPK inflammatory signaling pathways, Nrf2 oxidative stress signaling pathway, and TGF-β1/Smad 2/3 fibrosis signaling pathway, which referenced to multiple targets like TNF-α, IL-6, IL-8, TIMP-1, MMP, AKT, JAK3, IKK, PI3K, HO-1, MAPK, P38, ERK, etc. Current challenges and future directions in this promising field are also discussed at the end of this review. For the convenience of the readers, this review is divided into ten parts according to the structures of potential natural small molecular compounds. We hope that this review brings a quick look and provides some inspiration for the research of COPD." @default.
- W4220661857 created "2022-04-03" @default.
- W4220661857 creator A5020286464 @default.
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- W4220661857 creator A5087352334 @default.
- W4220661857 date "2022-03-24" @default.
- W4220661857 modified "2023-10-16" @default.
- W4220661857 title "Potential Natural Small Molecular Compounds for the Treatment of Chronic Obstructive Pulmonary Disease: An Overview" @default.
- W4220661857 cites W1534300078 @default.
- W4220661857 cites W1536163765 @default.
- W4220661857 cites W1538480688 @default.
- W4220661857 cites W1549435077 @default.
- W4220661857 cites W1643846079 @default.
- W4220661857 cites W1894829161 @default.
- W4220661857 cites W1896150680 @default.
- W4220661857 cites W1918240808 @default.
- W4220661857 cites W1966365711 @default.
- W4220661857 cites W1972122681 @default.
- W4220661857 cites W1973025429 @default.
- W4220661857 cites W1991618364 @default.
- W4220661857 cites W1994571273 @default.
- W4220661857 cites W2006430543 @default.
- W4220661857 cites W2007591248 @default.
- W4220661857 cites W2012307176 @default.
- W4220661857 cites W2015291113 @default.
- W4220661857 cites W2026570474 @default.
- W4220661857 cites W2043872253 @default.
- W4220661857 cites W2049994612 @default.
- W4220661857 cites W2061689949 @default.
- W4220661857 cites W2064480152 @default.
- W4220661857 cites W2069307976 @default.
- W4220661857 cites W2076054816 @default.
- W4220661857 cites W2087774078 @default.
- W4220661857 cites W2092471151 @default.
- W4220661857 cites W2093117593 @default.
- W4220661857 cites W2099627512 @default.
- W4220661857 cites W2106232279 @default.
- W4220661857 cites W2114406959 @default.
- W4220661857 cites W2128399547 @default.
- W4220661857 cites W2145932816 @default.
- W4220661857 cites W2149648467 @default.
- W4220661857 cites W2153703727 @default.
- W4220661857 cites W2163008651 @default.
- W4220661857 cites W2190148081 @default.
- W4220661857 cites W2211781561 @default.
- W4220661857 cites W2264653197 @default.
- W4220661857 cites W2308684179 @default.
- W4220661857 cites W2401306489 @default.
- W4220661857 cites W2417181367 @default.
- W4220661857 cites W2477133542 @default.
- W4220661857 cites W2486771080 @default.
- W4220661857 cites W2509863237 @default.
- W4220661857 cites W2511481914 @default.
- W4220661857 cites W2514009978 @default.
- W4220661857 cites W2534536090 @default.
- W4220661857 cites W2536432928 @default.
- W4220661857 cites W2552559219 @default.
- W4220661857 cites W2552567545 @default.
- W4220661857 cites W2556362204 @default.
- W4220661857 cites W2558762309 @default.
- W4220661857 cites W2563292177 @default.
- W4220661857 cites W2570651197 @default.
- W4220661857 cites W2593392964 @default.
- W4220661857 cites W2597963642 @default.
- W4220661857 cites W2599496392 @default.
- W4220661857 cites W2600511160 @default.
- W4220661857 cites W2603043313 @default.
- W4220661857 cites W2606242876 @default.
- W4220661857 cites W2622621620 @default.
- W4220661857 cites W2666549096 @default.
- W4220661857 cites W2744408082 @default.
- W4220661857 cites W2749236722 @default.
- W4220661857 cites W2756462278 @default.
- W4220661857 cites W2757386642 @default.
- W4220661857 cites W2761094006 @default.
- W4220661857 cites W2771713846 @default.
- W4220661857 cites W2773957560 @default.
- W4220661857 cites W2780176148 @default.
- W4220661857 cites W2786893950 @default.
- W4220661857 cites W2789741434 @default.
- W4220661857 cites W2791676985 @default.
- W4220661857 cites W2792179957 @default.
- W4220661857 cites W2798126480 @default.
- W4220661857 cites W2801241777 @default.
- W4220661857 cites W2804589543 @default.
- W4220661857 cites W2810978759 @default.
- W4220661857 cites W2811396003 @default.
- W4220661857 cites W2872234236 @default.
- W4220661857 cites W2883814091 @default.
- W4220661857 cites W2885614381 @default.
- W4220661857 cites W2886180961 @default.
- W4220661857 cites W2891484900 @default.
- W4220661857 cites W2895606553 @default.
- W4220661857 cites W2896078954 @default.
- W4220661857 cites W2905311179 @default.