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• W4220662446 endingPage "121167" @default.
• W4220662446 startingPage "121167" @default.
• W4220662446 abstract "Cysteine (Cys), an essential biological amino acid, participates several crucial functions in various physiological and pathological processes. The sensitive and specific detection of Cys is of great significance for understanding its biological function to disease diagnosis. Herein, we designed and synthesized a simple fluorescence sensor 2-(benzothiophen-2-yl)-4-oxo-4H-chromen-3-yl acrylate (BTCA) composed of a flavonol skeleton as the fluorophore and acrylic ester group as the recognition receptor. Probe BTCA displayed high selectivity and extremely fast response toward Cys in phosphate buffer solution in the presence of other competitive species even Homocysteine (Hcy) and Glutathione (GSH) owing to a specific conjugate addition-cyclization reaction between the acrylate moiety and Cys. The photoluminescence mechanism of probe BTCA toward Cys was modulated by excited state intramolecular proton transfer (ESIPT) process. The sensing property for Cys was studied by UV-Visible, fluorescence spectrophotometric analyses and time-dependent density functional theory (TD-DFT) calculations, those results indicated that probe BTCA possessed excellent sensitivity, higher specificity, dramatically naked-eye fluorescence enhancement (30-fold), high anti-interference ability, especially immediate response speed (within 40 s). Additionally, the practicability of sensor BTCA in exogenous and endogenous Cys imaging in living cells and zebrafish was elucidated as well, suggesting that it has remarkedly diagnostic significance in physiological and pathological process." @default.
• W4220662446 created "2022-04-03" @default.
• W4220662446 creator A5017459794 @default.
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• W4220662446 date "2022-07-01" @default.
• W4220662446 modified "2023-09-23" @default.
• W4220662446 title "A simple “turn-on” fluorescent probe capable of recognition cysteine with rapid response and high sensing in living cells and zebrafish" @default.
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• W4220662446 doi "https://doi.org/10.1016/j.saa.2022.121167" @default.
• W4220662446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35316627" @default.
• W4220662446 hasPublicationYear "2022" @default.
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