Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220664678> ?p ?o ?g. }
- W4220664678 endingPage "10" @default.
- W4220664678 startingPage "1" @default.
- W4220664678 abstract "Hepatocellular carcinoma (HCC) is the fourth main reason of cancer-related death. Codonopsis pilosula is a commonly used traditional Chinese medicine (TCM) for patients with HCC. However, its potential mechanism for treatment of HCC remains unclear. Here, we used transcriptomics and network pharmacology to explore the potential molecular mechanisms of Codonopsis pilosula. In our study, twelve differentially expressed genes (DEGs) (5 upregulated and 7 downregulated) of Codonopsis pilosula treating HepG2 cells (a kind of HCC cell) were identified. Among the 12 DEGs, HMOX1 may play an essential role. Codonopsis pilosula mainly affects the mineral absorption pathway in HCC. We acquired 2957, 1877, and 255 targets from TCMID, SymMap, and TCMSP, respectively. Codonopsis pilosula could upregulate HMOX1 via luteolin, capsaicin, and sulforaphane. Our study provided new understanding of the potential pharmacological mechanisms of Codonopsis pilosula in treating HCC and pointed out a direction for further experimental research." @default.
- W4220664678 created "2022-04-03" @default.
- W4220664678 creator A5014522956 @default.
- W4220664678 creator A5026620854 @default.
- W4220664678 creator A5031785945 @default.
- W4220664678 creator A5080744549 @default.
- W4220664678 date "2022-03-27" @default.
- W4220664678 modified "2023-10-17" @default.
- W4220664678 title "Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma" @default.
- W4220664678 cites W1757990252 @default.
- W4220664678 cites W1910661068 @default.
- W4220664678 cites W1975275493 @default.
- W4220664678 cites W1981239378 @default.
- W4220664678 cites W2008851677 @default.
- W4220664678 cites W2035618305 @default.
- W4220664678 cites W2044375122 @default.
- W4220664678 cites W2069213289 @default.
- W4220664678 cites W2082358366 @default.
- W4220664678 cites W2083429514 @default.
- W4220664678 cites W2105668062 @default.
- W4220664678 cites W2124679671 @default.
- W4220664678 cites W2130479394 @default.
- W4220664678 cites W2136033624 @default.
- W4220664678 cites W2146512944 @default.
- W4220664678 cites W2159675211 @default.
- W4220664678 cites W2160260402 @default.
- W4220664678 cites W2211968863 @default.
- W4220664678 cites W2241760375 @default.
- W4220664678 cites W2259037852 @default.
- W4220664678 cites W2283337148 @default.
- W4220664678 cites W2318436667 @default.
- W4220664678 cites W2342805349 @default.
- W4220664678 cites W2563886529 @default.
- W4220664678 cites W2597884957 @default.
- W4220664678 cites W2736730167 @default.
- W4220664678 cites W2766490148 @default.
- W4220664678 cites W2801683799 @default.
- W4220664678 cites W2807489487 @default.
- W4220664678 cites W2885709068 @default.
- W4220664678 cites W2891088504 @default.
- W4220664678 cites W2893159429 @default.
- W4220664678 cites W2893438768 @default.
- W4220664678 cites W2897985606 @default.
- W4220664678 cites W2899291554 @default.
- W4220664678 cites W2900569176 @default.
- W4220664678 cites W2901030744 @default.
- W4220664678 cites W2905137137 @default.
- W4220664678 cites W2937950765 @default.
- W4220664678 cites W2944039552 @default.
- W4220664678 cites W2944801277 @default.
- W4220664678 cites W2961807409 @default.
- W4220664678 cites W2964447635 @default.
- W4220664678 cites W2968489920 @default.
- W4220664678 cites W2984497827 @default.
- W4220664678 cites W2990323558 @default.
- W4220664678 cites W3005987050 @default.
- W4220664678 cites W3008432654 @default.
- W4220664678 cites W3012491782 @default.
- W4220664678 cites W3034594171 @default.
- W4220664678 cites W3044854927 @default.
- W4220664678 cites W3047211571 @default.
- W4220664678 cites W3088665686 @default.
- W4220664678 cites W3098351509 @default.
- W4220664678 cites W3108110268 @default.
- W4220664678 cites W3136967973 @default.
- W4220664678 cites W3152960122 @default.
- W4220664678 cites W3153799043 @default.
- W4220664678 cites W3185426724 @default.
- W4220664678 cites W3195159703 @default.
- W4220664678 cites W3211968758 @default.
- W4220664678 cites W3217798540 @default.
- W4220664678 cites W4206670923 @default.
- W4220664678 cites W4210512211 @default.
- W4220664678 cites W4232620598 @default.
- W4220664678 doi "https://doi.org/10.1155/2022/1340194" @default.
- W4220664678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35388300" @default.
- W4220664678 hasPublicationYear "2022" @default.
- W4220664678 type Work @default.
- W4220664678 citedByCount "5" @default.
- W4220664678 countsByYear W42206646782022 @default.
- W4220664678 countsByYear W42206646782023 @default.
- W4220664678 crossrefType "journal-article" @default.
- W4220664678 hasAuthorship W4220664678A5014522956 @default.
- W4220664678 hasAuthorship W4220664678A5026620854 @default.
- W4220664678 hasAuthorship W4220664678A5031785945 @default.
- W4220664678 hasAuthorship W4220664678A5080744549 @default.
- W4220664678 hasBestOaLocation W42206646781 @default.
- W4220664678 hasConcept C104317684 @default.
- W4220664678 hasConcept C111472728 @default.
- W4220664678 hasConcept C138885662 @default.
- W4220664678 hasConcept C150194340 @default.
- W4220664678 hasConcept C162317418 @default.
- W4220664678 hasConcept C502942594 @default.
- W4220664678 hasConcept C54355233 @default.
- W4220664678 hasConcept C60644358 @default.
- W4220664678 hasConcept C71924100 @default.
- W4220664678 hasConcept C86803240 @default.
- W4220664678 hasConcept C89611455 @default.