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- W4220671330 abstract "Biomarkers are of great importance in the prediction of onset and follow-up of patients with Huntington’s disease (HD). Neuroimaging is a convenient biomarker, because of its non-invasive character. Since technology is continuously evolving, we are increasingly able to visualize detailed neural structures and functions. Furthermore, it could also identify new targets for therapeutic interventions. In this chapter, we review findings in neuroimaging research applied to HD. First, we will describe the neuroanatomical structures and cellular processes, which are important in the pathophysiology of HD and are therefore particularly interesting to focus on. We will then discuss the different imaging modalities; from structural to functional, from commonly used to novel imaging strategies. Striatal- and cortical-volume loss on conventional MRI and decrease in uptake of radiotracers on PET are currently the most robust markers of disease progression. The use of other MRI-metabolites, specific PET radioligands, DTI, and fMRI may have the potential to detect HD pathology earlier and more accurately but needs further investigation. These neuroimaging markers, possibly combined, can be useful clinical outcome measures in clinical trials and could improve the management and treatment of future patients." @default.
- W4220671330 created "2022-04-03" @default.
- W4220671330 creator A5007807143 @default.
- W4220671330 creator A5026173435 @default.
- W4220671330 creator A5059663745 @default.
- W4220671330 creator A5065161156 @default.
- W4220671330 date "2022-10-26" @default.
- W4220671330 modified "2023-09-25" @default.
- W4220671330 title "Neuroimaging Biomarkers for Huntington’s Disease" @default.
- W4220671330 cites W1149926701 @default.
- W4220671330 cites W1179800764 @default.
- W4220671330 cites W1503169263 @default.
- W4220671330 cites W1514831034 @default.
- W4220671330 cites W1540114528 @default.
- W4220671330 cites W1552525306 @default.
- W4220671330 cites W1557312783 @default.
- W4220671330 cites W1591042602 @default.
- W4220671330 cites W1598342602 @default.
- W4220671330 cites W1645205604 @default.
- W4220671330 cites W1834161563 @default.
- W4220671330 cites W1844862277 @default.
- W4220671330 cites W1904647953 @default.
- W4220671330 cites W1965552702 @default.
- W4220671330 cites W1966491155 @default.
- W4220671330 cites W1967133011 @default.
- W4220671330 cites W1973319761 @default.
- W4220671330 cites W1973665858 @default.
- W4220671330 cites W1973909957 @default.
- W4220671330 cites W1974316717 @default.
- W4220671330 cites W1974790023 @default.
- W4220671330 cites W1978776432 @default.
- W4220671330 cites W1983355263 @default.
- W4220671330 cites W1985231573 @default.
- W4220671330 cites W1987404072 @default.
- W4220671330 cites W1988856835 @default.
- W4220671330 cites W1989339023 @default.
- W4220671330 cites W1990406694 @default.
- W4220671330 cites W1991731895 @default.
- W4220671330 cites W1992173091 @default.
- W4220671330 cites W1992898455 @default.
- W4220671330 cites W1993068285 @default.
- W4220671330 cites W1994536298 @default.
- W4220671330 cites W1995119071 @default.
- W4220671330 cites W1997911588 @default.
- W4220671330 cites W1998316883 @default.
- W4220671330 cites W2000561294 @default.
- W4220671330 cites W2001577031 @default.
- W4220671330 cites W2002613016 @default.
- W4220671330 cites W2003719759 @default.
- W4220671330 cites W2004460775 @default.
- W4220671330 cites W2005819729 @default.
- W4220671330 cites W2006372829 @default.
- W4220671330 cites W2006952111 @default.
- W4220671330 cites W2007689387 @default.
- W4220671330 cites W2008362268 @default.
- W4220671330 cites W2009110155 @default.
- W4220671330 cites W2010117446 @default.
- W4220671330 cites W2012015119 @default.
- W4220671330 cites W2015789019 @default.
- W4220671330 cites W2020488742 @default.
- W4220671330 cites W2021145301 @default.
- W4220671330 cites W2021549489 @default.
- W4220671330 cites W2021606554 @default.
- W4220671330 cites W2024954481 @default.
- W4220671330 cites W2025681964 @default.
- W4220671330 cites W2026801435 @default.
- W4220671330 cites W2027946127 @default.
- W4220671330 cites W2028362961 @default.
- W4220671330 cites W2031417185 @default.
- W4220671330 cites W2032120877 @default.
- W4220671330 cites W2034175695 @default.
- W4220671330 cites W2034294467 @default.
- W4220671330 cites W2035778678 @default.
- W4220671330 cites W2036685176 @default.
- W4220671330 cites W2038419059 @default.
- W4220671330 cites W2038560960 @default.
- W4220671330 cites W2038908449 @default.
- W4220671330 cites W2039232434 @default.
- W4220671330 cites W2039290817 @default.
- W4220671330 cites W2042716629 @default.
- W4220671330 cites W2043078214 @default.
- W4220671330 cites W2044190420 @default.
- W4220671330 cites W2047298395 @default.
- W4220671330 cites W2048599819 @default.
- W4220671330 cites W2048713258 @default.
- W4220671330 cites W2052810312 @default.
- W4220671330 cites W2054693278 @default.
- W4220671330 cites W2055542737 @default.
- W4220671330 cites W2058759341 @default.
- W4220671330 cites W2061162179 @default.
- W4220671330 cites W2062676916 @default.
- W4220671330 cites W2063917443 @default.
- W4220671330 cites W2064636913 @default.
- W4220671330 cites W2065402064 @default.
- W4220671330 cites W2067511615 @default.
- W4220671330 cites W2072697147 @default.
- W4220671330 cites W2072857392 @default.
- W4220671330 cites W2075033701 @default.
- W4220671330 cites W2076272048 @default.
- W4220671330 cites W2077463692 @default.