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- W4220672007 abstract "Site-specific drug delivery is a widespread and demanding area nowadays. Lipid-based nanoparticulate drug delivery systems have shown promising effects for targeting drugs among lymphatic systems, brain tissues, lungs, and skin. Recently, lipid nanoparticles are used for targeting the brain via the mucosal route for local therapeutic effects. Lipid nanoparticles (LNPs) can help in enhancing the efficacy and lowering the toxicities of anticancer drugs to treat the tumors, particularly in lymph after metastases of tumors. LNPs contain a non-polar core that can improve the absorption of lipophilic drugs into the lymph node and treat tumors. Cellular uptake of drugs can also be enhanced using LNPs and therefore, LNPs are the ideal carrier for treating intracellular infections such as leishmaniasis, tuberculosis and parasitic infection in the brain, etc. Furthermore, specific surface modifications with molecules like mannose, or PEG could improve the macrophage uptake and hence effectively eradicate parasites hiding in macrophages.An electronic literature search was conducted to update the advancements in the field of site-specific drug delivery utilizing lipid-based nanoparticles. A search of the Scopus database (https://www.scopus.com/home.uri) was conducted using the following keywords: lipid-based nanoparticles; site specific delivery.Solid lipid nanoparticles have shown site-specific targeted delivery to various organs including the liver, oral mucosa, brain, epidermis, pulmonary and lymphatic systems. These lipid-based systems showed improved bioavailability as well as reduced side effects. Therefore, the focus of this article is to review the recent research studies on LNPs for site-specific or targeting drug delivery." @default.
- W4220672007 created "2022-04-03" @default.
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- W4220672007 date "2022-02-01" @default.
- W4220672007 modified "2023-09-23" @default.
- W4220672007 title "Recent Updates on Applications of Lipid-Based Nanoparticles for Site- Specific Drug Delivery" @default.
- W4220672007 cites W1579046626 @default.
- W4220672007 cites W1581731557 @default.
- W4220672007 cites W1734250133 @default.
- W4220672007 cites W1825171923 @default.
- W4220672007 cites W1881226747 @default.
- W4220672007 cites W1963908918 @default.
- W4220672007 cites W1967406425 @default.
- W4220672007 cites W1970130895 @default.
- W4220672007 cites W1976131488 @default.
- W4220672007 cites W1976336238 @default.
- W4220672007 cites W1978777978 @default.
- W4220672007 cites W1980808550 @default.
- W4220672007 cites W1981468523 @default.
- W4220672007 cites W1990137645 @default.
- W4220672007 cites W1995643371 @default.
- W4220672007 cites W1999571009 @default.
- W4220672007 cites W2004014946 @default.
- W4220672007 cites W2005397347 @default.
- W4220672007 cites W2008131395 @default.
- W4220672007 cites W2010036027 @default.
- W4220672007 cites W2012179823 @default.
- W4220672007 cites W2012427617 @default.
- W4220672007 cites W2013234354 @default.
- W4220672007 cites W2014537537 @default.
- W4220672007 cites W2016097547 @default.
- W4220672007 cites W2023182663 @default.
- W4220672007 cites W2023409826 @default.
- W4220672007 cites W2028761028 @default.
- W4220672007 cites W2029074248 @default.
- W4220672007 cites W2029506214 @default.
- W4220672007 cites W2030747032 @default.
- W4220672007 cites W2040405360 @default.
- W4220672007 cites W2041400910 @default.
- W4220672007 cites W2041986910 @default.
- W4220672007 cites W2044476200 @default.
- W4220672007 cites W2044903986 @default.
- W4220672007 cites W2045260358 @default.
- W4220672007 cites W2048364135 @default.
- W4220672007 cites W2050706602 @default.
- W4220672007 cites W2054189154 @default.
- W4220672007 cites W2055619398 @default.
- W4220672007 cites W2056700668 @default.
- W4220672007 cites W2056764794 @default.
- W4220672007 cites W2058162926 @default.
- W4220672007 cites W2062129180 @default.
- W4220672007 cites W2065817859 @default.
- W4220672007 cites W2065870072 @default.
- W4220672007 cites W2069265941 @default.
- W4220672007 cites W2069661123 @default.
- W4220672007 cites W2072366248 @default.
- W4220672007 cites W2074037814 @default.
- W4220672007 cites W2078481291 @default.
- W4220672007 cites W2081720519 @default.
- W4220672007 cites W2089292074 @default.
- W4220672007 cites W2090088751 @default.
- W4220672007 cites W2090392987 @default.
- W4220672007 cites W2090429604 @default.
- W4220672007 cites W2093642159 @default.
- W4220672007 cites W2095471092 @default.
- W4220672007 cites W2111211179 @default.
- W4220672007 cites W2113755163 @default.
- W4220672007 cites W2115533786 @default.
- W4220672007 cites W2137397041 @default.
- W4220672007 cites W2142488275 @default.
- W4220672007 cites W2143698756 @default.
- W4220672007 cites W2171638781 @default.
- W4220672007 cites W2282554947 @default.
- W4220672007 cites W2340049980 @default.
- W4220672007 cites W2531369466 @default.
- W4220672007 cites W2545660909 @default.
- W4220672007 cites W2565464060 @default.
- W4220672007 cites W2605158646 @default.
- W4220672007 cites W2605628302 @default.
- W4220672007 cites W2606662217 @default.
- W4220672007 cites W2616129231 @default.
- W4220672007 cites W2620608786 @default.
- W4220672007 cites W2763868136 @default.
- W4220672007 cites W2769248848 @default.
- W4220672007 cites W2773689996 @default.
- W4220672007 cites W2793629808 @default.
- W4220672007 cites W2802212303 @default.
- W4220672007 cites W2803833798 @default.
- W4220672007 cites W2885749151 @default.
- W4220672007 cites W2886522842 @default.
- W4220672007 cites W2892070531 @default.
- W4220672007 cites W2895148573 @default.
- W4220672007 cites W2904780125 @default.
- W4220672007 cites W2909579525 @default.
- W4220672007 cites W2917437992 @default.
- W4220672007 cites W2936858823 @default.